High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block

Annals of the Rheumatic Diseases
Anna LisneyThomas Dörner

Abstract

Autoimmune congenital heart block (CHB) is associated with placental transcytosis of maternal autoantibodies directed against Ro/SS-A and La/SS-B. However, only about 2% of children born to mothers with the respective antibodies are affected, indicating that further risk factors exist, which are not yet fully understood. In this study, we investigated whether a maternal type I interferon (IFN) signature represents a risk factor for the development of CHB. Blood samples, clinical data and serological parameters from 9 women with CHB pregnancies, 14 pregnant women with antibodies against Ro/SS-A but without a CHB complication and another 30 healthy pregnant women as controls were studied. SIGLEC1 expression was measured by flow cytometry and was correlated to plasma IFN-α levels measured by ELISA, and IFN-γ-induced protein 10 (IP-10) levels measured by Bio-Plex technique. Mothers of affected children had a significantly higher expression of SIGLEC1 (p=0.0034) and IFN-α (p=0.014), but not of IP-10 (p=0.14, all MWU) compared to mothers of unaffected children. SIGLEC1 and IFN-α expression were reduced by hydroxychloroquine and oral glucocorticoids. High expression of SIGLEC1 in pregnant women with autoantibodies against Ro/SS-A indi...Continue Reading

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Citations

Jun 12, 2018·Current Opinion in Rheumatology·Gudny Ella ThorlaciusLars Rönnblom
Sep 7, 2018·Annals of the Rheumatic Diseases·Lucas L van den HoogenTimothy R D J Radstake
Apr 28, 2020·Emerging Microbes & Infections·Xiaoxuan SunMiaojia Zhang
Oct 8, 2019·Cardiovascular Research·Hemant SuryawanshiThomas Tuschl
Jan 1, 2020·Clinical & Translational Immunology·Shereen OonNicholas J Wilson
Mar 21, 2020·The Journal of Antimicrobial Chemotherapy·Dan ZhouQiang Tong
Feb 9, 2020·Nature Reviews. Rheumatology·Eva Schrezenmeier, Thomas Dörner
Jun 25, 2020·International Journal of Molecular Sciences·Przemyslaw WielgatHalina Car
Dec 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert M ClancyJill P Buyon
Jul 10, 2020·Indian Journal of Clinical Biochemistry : IJCB·Amit PalRajendra Prasad
Oct 3, 2020·Annals of the Rheumatic Diseases·Margarita IvanchenkoMarie Wahren-Herlenius
Nov 15, 2020·Scandinavian Journal of Immunology·Aurelie AmbrosiMarie Wahren-Herlenius
Feb 10, 2021·Clinical Rheumatology·N Martínez-SánchezJ L Bartha
Jan 9, 2021·Frontiers in Pediatrics·Sara De CarolisSilvia Salvi
Feb 16, 2021·Frontiers in Immunology·Huimin ZhouShengjun Wang
Mar 30, 2021·Frontiers in Immunology·Hector Rincon-ArevaloThomas Dörner
May 11, 2021·Frontiers in Immunology·Annika WiedemannThomas Dörner

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