High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer

Journal of breast cancer
Jongmin SimKiseok Jang

Abstract

Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome. High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression. Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes.

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Citations

Oct 28, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cheng FangXian-Tao Zeng
Apr 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shufang Wei, Weiyuan Ma
Apr 23, 2019·DNA and Cell Biology·Li Huang, Xiangyu Liu
Aug 23, 2019·International Journal of Molecular Sciences·Bonita ShinMousumi Majumder
Jan 7, 2020·Oncotarget·Eleni ZografosMeletios-Athanasios Dimopoulos
Dec 24, 2018·American Journal of Physiology. Endocrinology and Metabolism·Zhuoying HuHugh S Taylor
Feb 26, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhaojun RenXiujuan Li
Sep 26, 2020·Journal of Receptor and Signal Transduction Research·Kai SangLei Yu

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
targetscan
SurvMicro

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