High mite-allergen exposure increases the risk of sensitization in atopic children and young adults.

The Journal of Allergy and Clinical Immunology
S LauU Wahn

Abstract

Concentrations of major allergens of Dermatophagoides pteronyssinus (Dpt) and D. farinae (Df), Der p I and Der f I, were determined in 183 dust samples of mattresses of 133 atopic and 50 nonatopic children by a sandwich-type ELISA. Atopic children and young adults living in houses with high levels of Der p I and Der f I (greater than or equal to 2000 ng/gm of dust) were found to have significantly higher serum IgE levels to Dpt and Df (p less than 0.0001) compared to patients with low mite-allergen exposure. Washed leukocytes of 55 atopic children and 14 control subjects were investigated for in vitro histamine release to serial dilutions of Der p I; 86% of highly exposed (greater than or equal to 10,000 ng/gm) children demonstrated positive histamine release in response to Der p I compared to 17% in the group with very low exposure (less than 400 ng/gm). There was a positive correlation between basophil sensitivity (rs = 0.6; p less than 0.0001) and reactivity (rs = 0.54; p less than 0.0001) to Der p I and mite-allergen exposure. The relative risk for sensitization in the highly exposed group versus the group with very low exposure was sevenfold to 32-fold increased. We conclude that high concentrations of mite allergen (great...Continue Reading

Citations

Jan 1, 1992·International Archives of Occupational and Environmental Health·X Baur, V Liebers
Nov 1, 1992·Experimental & Applied Acarology·R Sporik, T A Platts-Mills
Aug 8, 2002·Current Allergy and Asthma Reports·Adnan Custovic, Clare S Murray
Aug 8, 2002·Current Allergy and Asthma Reports·Enrique Fernández-Caldas
Jan 24, 2002·Clinical Reviews in Allergy & Immunology·R Michael Sly
Jul 1, 1994·The Journal of Allergy and Clinical Immunology·J KuehrW Karmaus
Dec 15, 1990·Lancet
Apr 1, 1989·Current Opinion in Immunology·M D Chapman
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Samuel J ArbesDarryl C Zeldin
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·T A Platts-MillsP W Heymann
Dec 1, 1991·Current Opinion in Immunology·T A Platts-Mills
Oct 31, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Seung-Hyun ChoDavid Bernstein
Sep 25, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sue-Hsien ChenJing-Long Huang
Jun 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·L Borish
May 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K HussR G Hamilton
May 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A BahirA Mandelberg
Jan 30, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chan-Yeung MoiraAllan Becker
Oct 12, 2002·Paediatric Respiratory Reviews·Susanne LauUNKNOWN MAS Group
Aug 2, 2000·Allergy·U Wahn
Apr 27, 2000·Allergy·M J Torres-GalvánF Sánchez-García
Feb 13, 2003·Allergy·G Moscato, L Perfetti
Mar 17, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J L HuangK H Hsieh
May 10, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Susanne LauUlrich Wahn
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A MahmicL Young
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H YsselJ Bousquet
Jun 26, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C GutgesellC Neumann
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O S Von EhrensteinR von Kries
Aug 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J HyndmanT W Higenbottam
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R L BergmannU Wahn
Jan 31, 2002·Mediators of Inflammation·A Custovic, A Woodcock
Aug 6, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Robert A Wood
Jun 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Bousquet, P Burney
Oct 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M WittemanR C Aalberse
May 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T NagakuraK Maekawa
Mar 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L K DotterudE S Falk

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