High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation

The European Respiratory Journal
P SheenJon S Friedland

Abstract

Tuberculosis (TB) pleural disease is complicated by extensive tissue destruction. Matrix metalloproteinase (MMP)-1 and -9 are implicated in immunopathology of pulmonary and central nervous system TB. There are few data on MMP activity in TB pleurisy. The present study investigated MMP-1, -2 and -9 and their specific inhibitors (tissue inhibitor of metalloproteinase (TIMP)-1 and -2) in tuberculous effusions, and correlated these with clinical and histopathological features. Clinical data, routine blood tests, and pleural fluid/biopsy material were obtained from 89 patients presenting with pleural effusions in a TB-endemic area. MMP-1, -2 and -9 were measured by zymography or western blot, and TIMP-1 and -2 by ELISA. Pleural biopsies were examined microscopically, cultured for acid-alcohol fast bacilli and immunostained for MMP-9. Tuberculous pleural effusions contained the highest concentrations of MMP-9 compared with malignant effusions or heart failure transudates. MMP-9 concentrations were highest in effusions from patients with granulomatous biopsies: median (interquartile range) 108 (61-218) pg x mL(-1) versus 43 (12-83) pg x mL(-1) in those with nongranulomatous pleural biopsies. MMP-1 and -2 were not upregulated in tuberc...Continue Reading

Citations

Mar 27, 2012·Pulmonary Medicine·T HassanN G McElvaney
Oct 24, 2012·International Journal of Biological Sciences·Wen-Yeh HsiehChih-Sheng Lin
Dec 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chuan-Chin HuangMegan Murray
Apr 10, 2014·American Journal of Respiratory and Critical Care Medicine·Catherine W M OngJon S Friedland
Oct 3, 2014·Experimental Lung Research·Ana G Ramos-MartínezCarmen J Serrano
Oct 17, 2015·European Journal of Immunology·Sambasivan VenkatasubramanianRamakrishna Vankayalapati
Apr 10, 2015·The Tohoku Journal of Experimental Medicine·Ki-Eun HwangHak-Ryul Kim
Oct 19, 2013·European Journal of Immunology·Rebecca TadokeraRobert J Wilkinson
Oct 2, 2009·European Journal of Immunology·Martin BeisiegelStefan H E Kaufmann
Jan 16, 2016·Interactive Cardiovascular and Thoracic Surgery·Alfonso FiorelliAngelina Di Carlo
Jun 22, 2010·Heart & Lung : the Journal of Critical Care·Emmet E McGrathPaul B Anderson
Apr 4, 2013·Critical Reviews in Biochemistry and Molecular Biology·Jennifer VandoorenGhislain Opdenakker
Jul 8, 2016·International Journal of Experimental Pathology·Shahnawaz MajeedSadhna Sharma
Nov 4, 2016·Lung·Lisete Ribeiro TeixeiraMilena Marques Pagliarelli Acencio
Nov 9, 2016·Frontiers in Immunology·Hlumani Ndlovu, Mohlopheni J Marakalala
Nov 12, 2009·Expert Review of Neurotherapeutics·Vinod Kumar Gupta
Apr 21, 2012·Nature Reviews. Immunology·Lalita Ramakrishnan
Feb 20, 2018·Experimental and Therapeutic Medicine·Qiu-Yue LiuZong-De Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.