High-mobility group box 1 as a surrogate prognostic marker in dogs with systemic inflammatory response syndrome

Journal of Veterinary Emergency and Critical Care
Do-Hyeon YuJinho Park

Abstract

To evaluate various surrogate markers associated with the inflammatory and counter-inflammatory responses with respect to mortality in dogs with systemic inflammatory response syndrome (SIRS). Prospective observational study. Veterinary Teaching Hospital. Twenty-eight dogs with naturally occurring diseases and SIRS from January 2007 to May 2009. Upon admission to the veterinary hospital, history and baseline data from the physical examination, including parameters previously defined for meeting SIRS criteria, were documented. Heparinized blood samples were collected and plasma cytokines interleukin-6 (IL-6), IL-10, and high-mobility group box 1 (HMGB1) were measured by sandwich ELISA. In nonsurvivors, median plasma HMGB1 concentrations (0.718 microg/L, interquartile range [IQR]; 0.300-1.626 microg/L) and the ratio of HMGB1 to IL-10 (2.236, IQR; 0.972-5.367) were significantly increased as compared with those found in survivors (0.300 microg/L, IQR; 0.300-0.312 microg/L for HMGB1; 1.017, IQR; 0.862-1.126 for the ratio of HMGB1 to IL-10, P=0.007 and 0.024, respectively). Plasma IL-6, IL-10, and the ratio of IL-6 to IL-10 were not significantly different between groups. Among the parameters studied, HMGB1 and the ratio of HMGB1 to...Continue Reading

References

Jan 11, 1995·JAMA : the Journal of the American Medical Association·M S Rangel-FraustoR P Wenzel
Feb 1, 1994·The Journal of Veterinary Medical Science·K YamashitaT Kotani
Mar 1, 1997·Journal of Veterinary Internal Medicine·C M OttoC Soter
Jul 10, 1999·Science·H WangK J Tracey
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Oct 8, 2003·Journal of Veterinary Internal Medicine·Armelle M de LaforcadeJohn E Rush
Oct 23, 2003·Cytogenetic and Genome Research·H Murua EscobarI Nolte
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey
Mar 9, 2005·Critical Care Medicine·Jonas Sundén-CullbergCarl Johan Treutiger
Feb 7, 2006·The Veterinary Journal·Mads Kjelgaard-HansenAsger L Jensen
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcin F OsuchowskiDaniel G Remick
Apr 13, 2007·FEBS Letters·Minou Adib-Conquy, Jean-Marc Cavaillon
Apr 26, 2007·Journal of Intensive Care Medicine·Eddy Jean-Baptiste
Sep 29, 2007·Critical Care Medicine·Marieke A D van ZoelenTom van der Poll
Feb 26, 2008·Intensive Care Medicine·Sari KarlssonEsko Ruokonen
May 10, 2008·Scandinavian Journal of Immunology·A CastellheimT E Mollnes
Jan 13, 2009·Acta Veterinaria Scandinavica·Ragnvi HagmanErika Karlstam

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Citations

Mar 13, 2012·Journal of Veterinary Internal Medicine·A E DeClueM Harmon
Mar 29, 2011·The Journal of Veterinary Medical Science·Taku MiyashoHiroshi Yokota
May 12, 2011·The Journal of Veterinary Medical Science·Asami IshidaHajime Tsujimoto
Feb 9, 2016·Diagnostics·Christin Pilzweger, Stefan Holdenrieder
Mar 10, 2015·Antioxidants & Redox Signaling·Daniel J WeberFletcher A White
Jan 22, 2015·Journal of Veterinary Emergency and Critical Care·Nathan W PetersonJames W Barr
Jun 20, 2015·Journal of Veterinary Emergency and Critical Care·Ivana UhrikovaJaroslav Doubek
Feb 12, 2017·The Journal of Small Animal Practice·T Krentz, S Allen
Apr 2, 2017·BMC Veterinary Research·Josipa KulešRenata Barić Rafaj
Apr 30, 2019·Journal of Veterinary Emergency and Critical Care·Kris GommerenDominique Peeters
Oct 27, 2017·Journal of Veterinary Emergency and Critical Care·Romy M HeilmannJames W Barr
Dec 14, 2017·Journal of Veterinary Emergency and Critical Care·Kris GommerenDominique Peeters
Jul 19, 2019·Frontiers in Veterinary Science·Pia Martiny, Robert Goggs
Oct 23, 2019·Journal of Veterinary Emergency and Critical Care·Robert Goggs, Jo-Annie Letendre
Dec 8, 2011·The Journal of Veterinary Medical Science·Do-Hyeon YuJinho Park
Nov 6, 2020·Journal of Veterinary Internal Medicine·Yoonhoi KooByeong-Teck Kang
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Michela PuglieseAnnamaria Passantino

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