High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease

Scandinavian Journal of Rheumatology
T HoshinaT Hara

Abstract

To investigate whether two proinflammatory cytokines, high mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) are involved in the development of Kawasaki disease (KD). Twenty-seven patients with KD were included in this study. Eleven patients with sepsis and 28 healthy children served as controls. Serum levels of HMGB1 and MIF were measured by corresponding enzyme-linked immunosorbent assay (ELISA) kits, respectively. Real-time polymerase chain reaction (PCR) was used to quantify the expression levels of genes encoding receptor for advanced glycation end-products (RAGE), an HMGB1 receptor, and CD74, an MIF receptor in peripheral blood mononuclear cells (PBMCs). Serum levels of HMGB1 and MIF in KD patients were the highest in the early acute phase and gradually decreased after defervescence. Serum HMGB1 and MIF levels in KD patients were significantly higher than those in controls (HMGB1, p<0.001; MIF, p<0.01). The expression levels of the RAGE gene and CD74 gene in KD patients were significantly higher than those in controls (RAGE, p<0.001; CD74, p<0.01). These data suggest that HMGB1 and MIF play an important role in immune responses in KD patients.

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Citations

May 8, 2014·Journal of Immunology Research·Sonal Mehra, Marvin J Fritzler
May 22, 2013·Clinical & Developmental Immunology·Toshiaki NakanoShigeru Goto
Apr 13, 2012·Autoimmunity Reviews·A W S de SouzaC G M Kallenberg
Jul 27, 2015·Autoimmunity Reviews·Chen WangCees G M Kallenberg
Oct 17, 2013·Clinical and Experimental Immunology·G A RamirezA A Manfredi
Jul 11, 2014·Molecular Aspects of Medicine·Rui KangDaolin Tang
May 8, 2015·Oncoimmunology·Ilkka LiikanenAkseli Hemminki
Jun 28, 2016·Clinical and Experimental Immunology·T HaraS Yamasaki
Feb 2, 2012·Nature Reviews. Rheumatology·Helena Erlandsson HarrisDavid S Pisetsky
Feb 13, 2020·Frontiers in Pediatrics·Seigo OkadaYuichi Ishikawa
Mar 23, 2020·Clinical Reviews in Allergy & Immunology·Rajni KumrahSurjit Singh
Mar 19, 2020·European Journal of Medical Research·Biying QianJianmei Zhao
May 9, 2014·European Journal of Pediatrics·Valeria ChiricoCarmelo Salpietro
Nov 4, 2020·Immunity, Inflammation and Disease·Bo LiKai Le
Feb 16, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shinichiro MorichiHisashi Kawashima
May 14, 2021·Clinical & Translational Immunology·Toshiro HaraYasunari Sakai
Jul 13, 2021·Frontiers in Pediatrics·Kaushal SharmaSurjit Singh

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