High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis

Journal of Molecular and Cellular Cardiology
Taro NarumiIsao Kubota

Abstract

Apoptosis of cardiomyocytes is thought to account for doxorubicin cardiotoxicity as it contributes to loss of myocardial tissue and contractile dysfunction. Given that high-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein capable of inhibiting apoptosis, we aimed to clarify the role of HMGB1 in heat shock protein beta 1 (HSPB1) expression during doxorubicin-induced cardiomyopathy. Mitochondrial damage, cardiomyocyte apoptosis, and cardiac dysfunction after doxorubicin administration were significantly attenuated in mice with cardiac-specific overexpression of HMGB1 (HMGB1-Tg) compared with wild type (WT) -mice. HSPB1 levels after doxorubicin administration were significantly higher in HMGB1-Tg mice than in WT mice. Transfection with HMGB1 increased the expression of HSPB1 at both the protein and mRNA levels, and HMGB1 inhibited mitochondrial dysfunction and apoptosis after exposure of cardiomyocytes to doxorubicin. HSPB1 silencing abrogated the inhibitory effect of HMGB1 on cardiomyocyte apoptosis. Doxorubicin increased the binding of HMGB1 to heat shock factor 2 and enhanced heat shock element promoter activity. Moreover, HMGB1 overexpression greatly enhanced heat shock element promoter activity. Silencing of heat...Continue Reading

References

Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
Jul 16, 1981·The New England Journal of Medicine·R C YoungC E Myers
Oct 16, 2002·Biochimica Et Biophysica Acta·Pattie S Green, Christiaan Leeuwenburgh
Aug 20, 2003·Molecular Biology of the Cell·Coralie PallierVincent Marechal
Oct 6, 2007·Cell Stress & Chaperones·Donald C WilkersonKevin D Sarge
Nov 3, 2007·Journal of Neuroscience Research·Jung-Bin KimJa-Kyeong Lee
Jun 19, 2008·Cardiovascular Research·Tatsuro KitaharaIsao Kubota
Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sabine S LangeKaren M Vasquez
Jun 25, 2009·Current Medicinal Chemistry·Cristina CarvalhoPaula I Moreira
Dec 18, 2009·Cardiology·Kanu ChatterjeeJoel S Karliner
Aug 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chang-Hoon WooJun-ichi Abe
Jun 7, 2011·Cell Metabolism·Daolin TangMichael T Lotze
Jun 22, 2011·Autophagy·Rui KangDaolin Tang
Oct 9, 2013·Biochemical and Biophysical Research Communications·Xianwei WangJawahar L Mehta
Dec 3, 2013·Biochemical and Biophysical Research Communications·Shunsuke NetsuIsao Kubota

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Citations

May 14, 2016·Acta Pharmaceutica Sinica. B·Qingjie ChenWenjun Yin
Apr 15, 2016·International Journal of Molecular Sciences·Shinpei KadowakiIsao Kubota
Sep 1, 2016·Journal of Cellular Physiology·Eleonora FoglioFederica Limana
May 10, 2018·Cell Biology International·Shanshan ZhouXiaoyi Shao
Feb 17, 2019·Journal of Cellular Physiology·Habib HaybarNajmaldin Saki
Jan 12, 2017·Cell Stress & Chaperones·Nikolaos CharmpilasNektarios Tavernarakis
Oct 12, 2018·Cellular and Molecular Life Sciences : CMLS·Angela RaucciMaurizio C Capogrossi
May 8, 2019·JACC. Basic to Translational Science·Angela Raucci, Maurizio C Capogrossi
May 8, 2019·JACC. Basic to Translational Science·Tetsuya TakahashiMasafumi Watanabe
Oct 29, 2020·Oxidative Medicine and Cellular Longevity·Li ZhangLingmei Qian
Aug 12, 2020·Life Sciences·Zhi ZhaoYing Yao
Apr 18, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abdul WahidXiaohong Tang

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