High mobility group box-1 protein acts as a coactivator of nuclear factor of activated T cells-2 in promoting interleukin-2 transcription

The International Journal of Biochemistry & Cell Biology
Hui LiuZhi-yong Sheng

Abstract

High mobility group box-1 protein, an abundant and conserved constituent of vertebrate nuclei, has recently been reported to be an endogenous immune signal [Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, et al. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Reports 2004;5:825-30]. High mobility group box-1 protein can trigger the release of interleukin-2 and interleukin-12 from lymphocytes. However, at present the underlying mechanism remains unknown. It has been clarified that nuclear factor of activated T cells-2 transduces most immunological signals in T cells and modulates the production of interleukin-2. So it is natural that we asked whether high mobility group box-1 protein could promote production of interleukin-2 in a nuclear factor of activated T cells-2-dependent way. Our experiments firstly showed that high mobility group box-1 protein could bind to nuclear factor of activated T cells-2 in vivo and in vitro. High mobility group box-1 protein cotransfection markedly upregulated the transcription activity of nuclear factor of activated T cells-2 in promoting interleukin-2 reporter gene transcription, which was demonstrated to be dose-dependent. Cotransfecti...Continue Reading

References

May 1, 1994·Trends in Biochemical Sciences·S S NerM E Churchill
Mar 21, 1998·Genes & Development·L JayaramanC Prives
Jul 10, 1999·Science·H WangK J Tracey
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·J M BrickmanM Ptashne
Feb 17, 2001·The Journal of Steroid Biochemistry and Molecular Biology·Q YeH E Zhau
Aug 22, 2001·Biochemistry·S MüllerS Knapp
Sep 5, 2001·Molecular and Cellular Biology·E D RossL J Maher
May 25, 2002·Molecular and Cellular Biology·Katherine MitsourasMichael Carey
Jan 28, 2004·The Journal of Cell Biology·Roberta PalumboMarco E Bianchi
Jul 24, 2004·EMBO Reports·Patrizia Rovere-QueriniAngelo A Manfredi
Mar 1, 2005·Journal of Leukocyte Biology·Huan YangKevin J Tracey
Oct 30, 2007·Journal of Molecular Biology·Micah J McCauleyMark C Williams
Nov 6, 2007·Immunological Reviews·Marco E Bianchi, Angelo A Manfredi
Feb 5, 2008·The Biochemical Journal·René AssenbergJean O Thomas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.