Abstract
High mobility group box-1 protein, an abundant and conserved constituent of vertebrate nuclei, has recently been reported to be an endogenous immune signal [Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, et al. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Reports 2004;5:825-30]. High mobility group box-1 protein can trigger the release of interleukin-2 and interleukin-12 from lymphocytes. However, at present the underlying mechanism remains unknown. It has been clarified that nuclear factor of activated T cells-2 transduces most immunological signals in T cells and modulates the production of interleukin-2. So it is natural that we asked whether high mobility group box-1 protein could promote production of interleukin-2 in a nuclear factor of activated T cells-2-dependent way. Our experiments firstly showed that high mobility group box-1 protein could bind to nuclear factor of activated T cells-2 in vivo and in vitro. High mobility group box-1 protein cotransfection markedly upregulated the transcription activity of nuclear factor of activated T cells-2 in promoting interleukin-2 reporter gene transcription, which was demonstrated to be dose-dependent. Cotransfecti...Continue Reading
References
Jul 8, 1988·Science·J P ShawG R Crabtree
May 1, 1994·Trends in Biochemical Sciences·S S NerM E Churchill
Jun 9, 1994·Nature·J P NorthropG R Crabtree
Mar 21, 1998·Genes & Development·L JayaramanC Prives
Jul 22, 1998·Molecular and Cellular Biology·V BoonyaratanakornkitD P Edwards
Jul 10, 1999·Science·H WangK J Tracey
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·J M BrickmanM Ptashne
Feb 17, 2001·The Journal of Steroid Biochemistry and Molecular Biology·Q YeH E Zhau
Aug 22, 2001·Biochemistry·S MüllerS Knapp
Aug 25, 2001·Blood·A KianiA Rao
Sep 5, 2001·Molecular and Cellular Biology·E D RossL J Maher
May 25, 2002·Molecular and Cellular Biology·Katherine MitsourasMichael Carey
Jan 28, 2004·The Journal of Cell Biology·Roberta PalumboMarco E Bianchi
Jul 17, 2004·Molecular Endocrinology·Dweepanita DasWilliam M Scovell
Jul 24, 2004·EMBO Reports·Patrizia Rovere-QueriniAngelo A Manfredi
Sep 7, 2004·The Journal of Biological Chemistry·Jana BarlicPhilip M Murphy
Mar 1, 2005·Journal of Leukocyte Biology·Huan YangKevin J Tracey
Oct 30, 2007·Journal of Molecular Biology·Micah J McCauleyMark C Williams
Nov 6, 2007·Immunological Reviews·Marco E Bianchi, Angelo A Manfredi
Feb 5, 2008·The Biochemical Journal·René AssenbergJean O Thomas
Citations
May 20, 2014·Neurochemical Research·Man LiYong Luo
Mar 10, 2015·Antioxidants & Redox Signaling·Daniel J WeberFletcher A White
Sep 8, 2011·Journal of Cellular Biochemistry·Sanghyun LeeMinhyung Lee
Mar 30, 2019·Photochemistry and Photobiology·David Kessel
Jun 28, 2014·International Journal of Molecular Medicine·Man LiYuan Li
Aug 8, 2021·International Journal of Molecular Sciences·Andrea CoppolaDavide Lauro