High Mobility Group Box 1/Toll-like Receptor 4 Signaling Increases GABRB3 Expression in Alcohol Exposure.

Neuropsychiatric Disease and Treatment
Guangtao SunZuoyi Huang

Abstract

Prefrontal cortex (PFC) and striatal neurotransmitter homeostasis is affected by alcohol dependence. In this study, the microarray dataset from the Gene Expression Omnibus (GEO) database were downloaded. The prefrontal and striatum data were cross-analyzed to reveal the co-effects of alcohol dependence on the two brain regions of mice. The GSE123114 microarray profile was downloaded from the GEO database, and differentially expressed genes (DEGs) between the two groups were acquired by GEO2R. KEGG analyses were performed to identify the pivotal pathways of these DEGs. Key differential gene expressions and their mechanism associated with alcohol exposure were investigated by an intraperitoneal alcohol model. A total of 13 overlapping DEGs from the PFC and striatal datasets of the GSE123114 microarray profile were identified, and they were significantly enriched in the morphine addiction pathway. The transcript levels and protein expression of Gabrb3 were consistent with the microarray data both in the PFC and striatum. The transcript levels of HMGB1, TLR4, TNFα and IL-1β were upregulated in the PFC and striatum of mice in the alcohol group. The HMGB1 inhibitor decreased Gabrb3 transcript and protein levels as well as TNFα and IL...Continue Reading

References

Sep 5, 1995·European Journal of Pharmacology·Z L Rossetti, S Carboni
Dec 19, 1998·Psychiatry Research·E P NobleR S Sparkes
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Seppo KähkönenRisto J Ilmoniemi
Feb 19, 2008·The Journal of Biological Chemistry·Arunesh SarasHanns Hatt
Jun 3, 2008·American Journal of Human Genetics·Miyabi TanakaAntonio V Delgado-Escueta
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Silvia Alfonso-LoechesConsuelo Guerri
May 31, 2011·Journal of Receptor and Signal Transduction Research·Malini KrishnamoorthyRodney J Nash
Mar 16, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Silvia RossiDiego Centonze
Aug 29, 2012·Alcoholism, Clinical and Experimental Research·Huiping ZhangJoel Gelernter
Feb 5, 2013·Antioxidants & Redox Signaling·Christina JankoMartin Herrmann
Jan 24, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Osama A AbulseoudDoo-Sup Choi
Nov 13, 2015·Alcohol·Heather Trantham-Davidson, L Judson Chandler
Jul 15, 2016·Behavioural Brain Research·Daniel Almeida da Silva E SilvaAna Lúcia Brunialti Godard
Feb 6, 2017·Neuropharmacology·Fulton T CrewsLeon G Coleman
Jul 18, 2017·Journal of Neurogenetics·Carolina de Paiva LimaAna Lúcia Brunialti Godard
Aug 14, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Agbonlahor OkhuaroboZakariya Sule
Oct 15, 2018·Progress in Neurobiology·Fawaz AlasmariYoussef Sari

❮ Previous
Next ❯

Software Mentioned

GEO2R

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.