High Mobility Group Box Protein 1 Serves as a Potential Prognostic Marker of Lung Cancer and Promotes Its Invasion and Metastasis by Matrix Metalloproteinase-2 in a Nuclear Factor-κ B-Dependent Manner

BioMed Research International
Xiaojin WuDongsheng Pei

Abstract

Several studies have reported a significant role of high mobility group box protein 1 (HMGB1) in lung cancer. Nevertheless, there is a lack of knowledge regarding the expression of HMGB1 and its correlation with the clinicopathological features of lung cancer. In addition, the potential molecular mechanisms underlying the role of HMGB1 in lung cancer are still unknown. We therefore investigated the clinicopathological and prognostic significance as well as the potential role of HMGB1 in the development and progression of lung cancer. HMGB1 expression in the tumor tissues of the cohort correlated with clinicopathological features. Moreover, lung cell migration and invasion were significantly increased after treatment with HMGB1. The matrix metalloproteinase-2 (MMP-2) expression and activity were upregulated after treatment with HMGB1, while the upregulated expression of MMP-2 stimulated by HMGB1 in lung cancer cells was significantly reduced with the blockage of si-p65. These results indicated that HMGB1 expression was significantly associated with lung cancer progression. We also showed that HMGB1 promoted lung cancer invasion and metastasis by upregulating the expression and activity of MMP-2 in an NF-κB-dependent manner. Take...Continue Reading

References

Aug 22, 2000·The Journal of Investigative Dermatology·U B HofmannD J Ruiter
Feb 12, 2004·Journal of Internal Medicine·H WangK J Tracey
Jun 28, 2005·Trends in Immunology·Ingrid E DumitriuPatrizia Rovere-Querini
Nov 4, 2005·American Journal of Physiology. Cell Physiology·Jong Sung ParkEdward Abraham
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jessica E EllermanMichael T Lotze
Jun 19, 2009·Respiratory Medicine·Guan-Hong ShangDian-Jie Lin
Nov 26, 2009·American Journal of Respiratory Cell and Molecular Biology·Po-Len LiuInn-Wen Chong
Jan 1, 2009·Folia Histochemica Et Cytobiologica·Wojciech NaumnikElzbieta Chyczewska
Jul 20, 2010·Amino Acids·T Klein, R Bischoff
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John C T WongIsabella T Tai
May 24, 2011·Cancer Research·Jitka FucikovaRadek Spísek
Sep 29, 2011·Advances in Experimental Medicine and Biology·Qingguo Ruan, Youhai H Chen
May 8, 2013·Experimental Lung Research·Shr-Yun ChiouWen-Jue Soong
Aug 24, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura ContiFederica Cavallo
Nov 20, 2013·Acta Biochimica Et Biophysica Sinica·Cailian ZhangJinran Zhang
Jan 1, 2013·Contemporary Oncology Współczesna Onkologia·Xiaohong ZhangJing Wang
Apr 1, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Dinç SürenCem Sezer
Jul 8, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jing-Luan WangNi-Na Sun
Mar 11, 2015·Advances in Experimental Medicine and Biology·K JakubowskaE Chyczewska
Mar 1, 2016·Scientific Reports·Kranthi Marella PanthPhilippe Lambin

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Citations

Aug 6, 2019·Frontiers in Immunology·Carolina M GorgulhoMichael T Lotze

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Methods Mentioned

BETA
chip
electrophoresis
zymography

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