High myopia is protective against diabetic retinopathy via thinning retinal vein: A report from Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT).

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Zhong LinYuan Bo Liang

Abstract

To investigate the association between high myopia and diabetic retinopathy, and its possible mechanism, in a northeastern Chinese population with type 2 diabetic mellitus. Patients were included from Fushun Diabetic Retinopathy Cohort Study. High myopia was defined as spherical equivalent of autorefraction less than -5D. A total of 1817 patients [688 (37.9%) diabetic retinopathy, 102 (5.6%) high myopia] were included. Compared to eyes without high myopia, the frequency of diabetic retinopathy and non-proliferative diabetic retinopathy was significantly less in eyes with high myopia (23.5% vs 38.7%, p = 0.002; 22.5% vs 35.3%, p = 0.005). Eyes with high myopia were less likely to have diabetic retinopathy (multivariate odds ratio, 95% confidence interval: 0.39, 0.22-0.68) or non-proliferative diabetic retinopathy (odds ratio, 95% confidence interval: 0.40, 0.23-0.70). High myopia was negatively associated with central retinal venular equivalent (multivariate β, 95% confidence interval: -37.1, -42.3 to -31.8, p < 0.001). Furthermore, central retinal venular equivalent (per 10 μm increase) had a significant association with diabetic retinopathy (odds ratio, 95% confidence interval: 1.24, 1.17-1.31) as well as non-proliferative dia...Continue Reading

References

Sep 19, 1992·BMJ : British Medical Journal·V PatelE Kohner
Oct 3, 2000·Ophthalmic Research·C Delaey, J Van De Voorde
Feb 24, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M H CuypersB C Polak
Apr 26, 2003·The British Journal of Ophthalmology·G DimitrovaS Kitano
Oct 17, 2003·Current Eye Research·Michael D KnudtsonBarbara E K Klein
Jul 6, 2004·Ophthalmology·Rohit VarmaUNKNOWN Los Angeles Latino Eye Study Group
Dec 25, 2004·Diabetes Care·UNKNOWN American Diabetes Association
May 26, 2007·American Journal of Ophthalmology·Annette KifleyPaul Mitchell
Sep 27, 2007·Ophthalmic Epidemiology·Barbara Eden Kobrin Klein
Jul 8, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xi Wei XieJost B Jonas
Jan 27, 2009·Ophthalmology·Feng Hua WangTien Yin Wong
Dec 25, 2009·Ophthalmology·Laurence Shen LimTien Yin Wong
Jan 12, 2010·Retina·Zvia Burgansky-EliashAdiel Barak
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Mar 5, 2011·Acta Ophthalmologica·Feng Hua WangUNKNOWN Handan Eye Study Group
Feb 15, 2012·Archives of Ophthalmology·Ronald KleinBarbara E K Klein
Mar 20, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Ko-Jen YangLing Yeung
May 26, 2012·Ophthalmology·Ryan Eyn Kidd ManEcosse L Lamoureux
Sep 26, 2013·Investigative Ophthalmology & Visual Science·Donghyun JeeSeungbum Kang
Oct 2, 2014·Investigative Ophthalmology & Visual Science·Ryan Eyn Kidd ManEcosse L Lamoureux
Nov 5, 2015·Diabetes Research and Clinical Practice·Xiang WangYunping Li
Sep 19, 2016·American Journal of Ophthalmology·Daniel L ChaoShan C Lin
May 20, 2019·American Journal of Ophthalmology·Ryan E K ManEcosse L Lamoureux

❮ Previous
Next ❯

Citations

Oct 29, 2021·Indian Journal of Ophthalmology·Rajvardhan AzadPrateek Nishant
Oct 29, 2021·Indian Journal of Ophthalmology·Jacquelyn N HamatiPadmaja K Rani
Oct 29, 2021·Indian Journal of Ophthalmology·Swapnil ThakurPadmaja Kumari Rani

❮ Previous
Next ❯

Software Mentioned

Statistical Analysis System
FS
DIRECT
IVAN
Integrative Vessel Analysis ( IVAN )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista de chirurgie, oncologie, radiologie, o. r. l., oftalmologie, stomatologie. Oftalmologie
D PopM Nuţă
Bulletin des sociétés d'ophtalmologie de France
J D Grange, J L Leynaud
Vestnik oftalmologii
A V Bol'shunov, I A Kulieva
Vestnik oftalmologii
M G MargolisM M Asadulina
© 2021 Meta ULC. All rights reserved