High-Na+ low-K+ UW cold storage solution reduces reperfusion injuries of the rat liver graft

Transplant International : Official Journal of the European Society for Organ Transplantation
H Ben AbdennebiO Boillot

Abstract

The isolated perfused rat liver model was used to assess graft viability after 24 h of cold preservation. Two solutions were compared for liver preservation: Belzer's original UW solution (high-K+ UW) and a solution containing the same components but with inverted concentrations of sodium and potassium (high-Na+ UW). During the 120 min of normothermic reperfusion, livers preserved in the high-Na+ UW solution released lower levels of creatine kinase-BB isoenzyme, transaminases (ALT and AST), and potassium than those preserved in the high-K+ UW solution. Bile flow and biliary excretion of indocyanine green increased when livers were preserved in the high-Na+ UW solution. We found no statistical differences for oxygen consumption and tissue ATP concentration. The results of this study support the concept that a high-Na+ UW solution is a more effective means of preserving rat livers, at least after 24 h of cold-storage and 120 min of reperfusion in the isolated perfused model, than the original high-K+ UW solution. Liver preservation in the high-Na+ UW solution reduces damage to sinusoidal endothelial and hepatocellular cells. The use of an extracellular-like Belzer cold storage solution eliminates potassium-related problems in col...Continue Reading

References

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Mar 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J J LemastersR G Thurman

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Citations

May 7, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jean Pierre FaureThierry Hauet
Feb 13, 2009·Clinical Transplantation·Ricardo CodasLionel Badet
May 26, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ismail Ben MosbahCarmen Peralta
Jul 29, 2004·Biochimica Et Biophysica Acta·Carole DoucetGerard Mauco
Apr 6, 2005·Transplantation Proceedings·L BadetX Martin
Aug 1, 2015·PloS One·Mohamed BejaouiJoan Rosselló-Catafau
Apr 28, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Lionel BadetXavier Martin
Oct 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miranda Bartels-StringerCornelis Kramers
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jean Pierre FaureThierry Hauet
Sep 19, 2006·World Journal of Gastroenterology : WJG·Hassen Ben AbdennebiOlivier Boillot
May 24, 2007·Transplantation·Mark-Hugo J MaathuisRutger J Ploeg
Sep 12, 2007·Journal of Gastroenterology and Hepatology·Narci C Teoh, Jennifer Hartley
Sep 4, 2015·The Journal of Pharmacology and Experimental Therapeutics·Mohamed BejaouiJoan Rosselló-Catafau
Mar 8, 2006·World Journal of Gastroenterology : WJG·Ismail Ben MosbahCarmen Peralta
Jan 17, 2015·World Journal of Gastroenterology : WJG·Mohamed BejaouiJoan Roselló-Catafau
Jul 5, 2007·Journal of Gastroenterology and Hepatology·Rosa Franco-GouCarmen Peralta
Apr 16, 2005·World Journal of Gastroenterology : WJG·Ying ChengNing Zhao
Aug 23, 2018·World Journal of Gastroenterology : WJG·Norma AlvaTeresa Carbonell

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