High natural killer cell number might identify stroke patients at risk of developing infections

Neurology. Neuroimmunology and Neuroinflammation
Sylvie De RaedtJacques De Keyser

Abstract

To investigate early changes in leukocyte subsets and autonomic function as predictors of the development of poststroke infections. We assessed the time course of leukocyte subsets in the blood of 59 patients with acute ischemic stroke. We divided the patients into 2 groups: those who developed infections during the first 7 days after stroke onset and those who did not. We measured urinary norepinephrine and epinephrine concentrations and pulse rate variability indices within 24 hours of admission. We found that the number of circulating natural killer (NK) cells within the first hours after stroke was higher in stroke patients who developed infections (mean 435 cells/mL; 95% confidence interval [CI] 321-588) than in stroke patients who did not develop infections (mean 236 cells/mL; 95% CI 186-300; p = 0.001). This was followed by a decrease in all lymphocyte subsets from admission to day 1, varying between 22% and 40%, which was not seen in patients without poststroke infection (mean increase varied between 2% and 23%; all p < 0.005). In the group that developed infections, pulse rate variability revealed a decreased high frequency component. These findings all remained significant after adjustment for age and stroke volume. H...Continue Reading

Citations

Dec 13, 2018·The EPMA Journal·Jiri PolivkaVladimir Rohan
Jun 30, 2019·Critical Care : the Official Journal of the Critical Care Forum·Allan PatinecJacques Le Pendu
Apr 5, 2017·Neural Plasticity·Marialuisa GandolfiSalvatore Chirumbolo
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen ChenNai-Hong Chen

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Methods Mentioned

BETA
urine collection
flow cytometry

Software Mentioned

SPSS
Kubios
GraphPad Prism

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