High nephron endowment protects against salt-induced hypertension

American Journal of Physiology. Renal Physiology
Kenneth A WalkerMichelle M Kett

Abstract

While low nephron number is associated with increased risk of developing cardiovascular and renal disease, the functional consequences of a high nephron number are unknown. We tested the hypothesis that a high nephron number provides protection against hypertensive and renal insults. Mean arterial pressure (MAP) and renal function were characterized in male wild-type (WT) and transforming growth factor-β2 heterozygous (Tgfb2(+/-)) mice under basal conditions and following a chronic high-salt diet. Kidneys were collected for unbiased stereological analysis. Baseline MAP and renal function were indistinguishable between genotypes. The chronic high-salt diet (5% NaCl for 4 wk followed by 8% NaCl for 4 wk) led to similar step-wise increases in urine volume, Na(+) excretion, and albuminuria in the genotypes. The 5% NaCl diet induced modest and similar increases in MAP (3.5 ± 1.6 and 3.4 ± 0.8 mmHg in WT and Tgfb2(+/-), respectively). After the step up to the 8% NaCl diet, MAP increased further in WT (+15.9 ± 5.1 mmHg), but not Tgfb2(+/-) (-0.1 ± 1.0 mmHg), mice. Nephron number was 30% greater in Tgfb2(+/-) than WT mice and was not affected by the chronic high-salt diet. Mean glomerular volume was lower in Tgfb2(+/-) than WT mice, an...Continue Reading

References

Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Dec 1, 1972·Annals of Biomedical Engineering·A C GuytonR D Manning
Jan 1, 1995·International Review of Cytology·J F Bertram
Dec 9, 1998·Kidney International·M Lelièvre-PégorierC Merlet-Bénichou
Feb 19, 2000·Biochemical and Biophysical Research Communications·A MaeshimaI Kojima
Apr 25, 2001·Kidney International·L A OrtizM Baum
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Annette J DahlyRichard J Roman
Jan 10, 2003·The New England Journal of Medicine·Gunhild KellerKerstin Amann
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·João P C MartinsAna D O Paixão
Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mai OtsBarry M Brenner
Apr 17, 2004·Kidney International·Stephen R DunnKumar Sharma
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·Josef CoreshMark J Sarnak
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hayley DickinsonKaren Moritz
Apr 27, 2007·Journal of the American Society of Nephrology : JASN·Lorine WilkinsonMelissa H Little
May 1, 2007·American Journal of Obstetrics and Gynecology·Roy MansanoMichael G Ross
Oct 30, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Noori MakaM Jane Black
Mar 5, 2008·Pediatric Research·Sunder Sims-LucasJohn F Bertram
Jun 27, 2008·American Journal of Physiology. Renal Physiology·Wayne D ComperLeileata M Russo
Mar 26, 2010·American Journal of Physiology. Renal Physiology·Leah-Anne M RutaMichelle M Kett
Dec 31, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michelle M Kett, Kate M Denton
May 3, 2011·PloS One·Kenneth A WalkerKaye L Stenvers
Aug 1, 2010·Journal of Developmental Origins of Health and Disease·W E HoyJ F Bertram

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Citations

Sep 11, 2013·PloS One·Seshini GurusingheMichelle M Kett
Apr 9, 2015·Clinical Kidney Journal·Nobuo TsuboiTakashi Yokoo
Apr 6, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jez HuangSunny Hartwig
Jan 16, 2015·Current Opinion in Pharmacology·Reetu R Singh, Kate M Denton
Aug 21, 2015·Nutrition Reviews·Anna E Stanhewicz, W Larry Kenney
Jun 19, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Go KanzakiTakashi Yokoo
Aug 23, 2016·PloS One·Stacey HokkeLuise A Cullen-McEwen
Jan 29, 2017·Physiological Genomics·Xuexiang Wang, Michael R Garrett
Jan 1, 2014·Canadian Journal of Kidney Health and Disease·Michel G ArsenaultSunny Hartwig
Jul 15, 2017·Frontiers in Pediatrics·Shari GurusingheChristine B Sethna

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