High neutrophil to lymphocyte ratio and decreased CD69+ NK cells represent a phenotype of high risk in early-stage breast cancer patients

OncoTargets and Therapy
Pablo MandóEstrella Mariel Levy

Abstract

Breast cancer (BC) is a highly heterogeneous disease presenting a broad range of clinical and molecular characteristics. In the past years, a growing body of evidence demonstrated that immune response plays a significant role in cancer outcome. However, immune prognostic markers are not completely validated in clinical practice in BC patients. With the aim to characterize immune features, several parameters were analyzed in peripheral blood at diagnosis of 85 nonmetastatic BC patients between April 2011 and July 2014. With a median follow-up of 38.6 months, peripheral blood analysis of BC patients (stages I, II, and III) showed that total lymphocyte and T lymphocyte counts were augmented in nonrelapsed patients. Also, a higher neutrophil-to-lymphocytes ratio was associated with prolonged disease-free survival. Natural killer cell receptor analysis revealed that early activation receptor CD69 was associated with a better outcome. This preliminary evidence is in accordance with the concept of immune surveillance. We suggest an "immune phenotype" that provides relevant prognostic information in early-stage BC patients and which could be useful in the decision-making process.

Citations

Sep 19, 2019·Cancers·Helen TowerKara Britt
Nov 18, 2020·Journal for Immunotherapy of Cancer·Chiara MassaBarbara Seliger
Jun 10, 2021·Oncoimmunology·Annat RaiterRinat Yerushalmi
Nov 20, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Pierluigi MarianiLuigi Laino

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Methods Mentioned

BETA
surgical resection
flow cytometry

Software Mentioned

Cellquest Pro
FlowJo
GraphPad
Stata14

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