Abstract
Hypothyroidism has been shown to contribute to enhanced atrial arrhythmogenesis, resulting in atrial fibrillation (AF) development in animal models and clinical populations. We aimed to elucidate whether high thyroid-stimulating hormone (TSH) levels are related to outcomes of catheter ablation of AF. Of 477 consecutive patients who underwent first-time pulmonary vein isolation-based radiofrequency catheter ablation of AF, 456 with TSH above the lower limit of the normal range (age, 65.5±9.9 years; men, 73.9%; paroxysmal AF, 56.8%) were analyzed for this study. Atrial tachyarrhythmia recurrence for 3 years was compared across groups with hypothyroidism (n=23) and TSH quartile groups with euthyroidism (normal-range TSH levels, n=433). Atrial tachyarrhythmia recurrence occurred in 179 patients (39%) after the first session. Patients with hypothyroidism had increased recurrence compared with patients with normal TSH levels (crude hazard ratio, 3.14 after the last session; P=0.001). When focusing on patients with normal TSH levels, recurrence-free survivals after both the first and last sessions were significantly reduced in euthyroid patients with the highest quartile of TSH levels (quartile 4) compared with others (quartiles 1-3)....Continue Reading
References
Aug 1, 1972·The Journal of Clinical Investigation·P J Snyder, R D Utiger
Feb 19, 2000·Annals of Internal Medicine·A E HakJ C Witteman
Oct 31, 2001·American Heart Journal·J AuerB Eber
Nov 30, 2005·Archives of Internal Medicine·John P WalshValdo Michelangeli
Oct 10, 2007·Circulation·Irwin Klein, Sara Danzi
May 26, 2009·The Annals of Thoracic Surgery·Young Joo ParkCheong Lim
Apr 25, 2012·Archives of Internal Medicine·Tinh-Hai ColletUNKNOWN Thyroid Studies Collaboration
Sep 17, 2013·Circulation. Arrhythmia and Electrophysiology·Youhua ZhangA Martin Gerdes
Dec 18, 2013·American Heart Journal·Eun-Jeong KimJared W Magnani
May 13, 2014·Journal of the American College of Cardiology·Efstratios I CharitosPaul D Ziegler
Jul 25, 2014·The American Journal of Medicine·Helene BruereNicolas Clementy
Aug 22, 2015·Journal of the American College of Cardiology·Mikhail S DzeshkaEduard Shantsila
Feb 24, 2016·Endocrine Connections·Akinori SairakuYasuki Kihara
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Jan 4, 2017·European Journal of Internal Medicine·Alessandro P DelitalaGiuseppe Delitala
Apr 13, 2017·The New England Journal of Medicine·David J StottUNKNOWN TRUST Study Group
Jun 10, 2017·JACC. Clinical Electrophysiology·Junaid A B ZamanJohn M Miller
Oct 13, 2017·Journal of Arrhythmia·Hugh CalkinsTeiichi Yamane
Oct 25, 2017·Circulation·Christine BaumgartnerUNKNOWN Thyroid Studies Collaboration
Nov 17, 2017·Circulation. Arrhythmia and Electrophysiology·Bing YangUNKNOWN STABLE-SR Investigators*
Citations
Jun 9, 2019·Endocrine·Jianqiang LiYue Li
Apr 25, 2020·International Journal of Molecular Sciences·Narcis TribulovaBarbara Szeiffova Bacova
Mar 12, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ryota YamauchiToyoaki Murohara
May 28, 2021·Heart and Vessels·Yuichi NinomiyaMitsuru Ohishi
Jul 13, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Yan PeiYawei Xu
Aug 11, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichi FuruiToyoaki Murohara