High-Normal Thyroid-Stimulating Hormone Shows a Potential Causal Association With Arrhythmia Recurrence After Catheter Ablation of Atrial Fibrillation

Journal of the American Heart Association
Itsuro MorishimaToyoaki Murohara

Abstract

Hypothyroidism has been shown to contribute to enhanced atrial arrhythmogenesis, resulting in atrial fibrillation (AF) development in animal models and clinical populations. We aimed to elucidate whether high thyroid-stimulating hormone (TSH) levels are related to outcomes of catheter ablation of AF. Of 477 consecutive patients who underwent first-time pulmonary vein isolation-based radiofrequency catheter ablation of AF, 456 with TSH above the lower limit of the normal range (age, 65.5±9.9 years; men, 73.9%; paroxysmal AF, 56.8%) were analyzed for this study. Atrial tachyarrhythmia recurrence for 3 years was compared across groups with hypothyroidism (n=23) and TSH quartile groups with euthyroidism (normal-range TSH levels, n=433). Atrial tachyarrhythmia recurrence occurred in 179 patients (39%) after the first session. Patients with hypothyroidism had increased recurrence compared with patients with normal TSH levels (crude hazard ratio, 3.14 after the last session; P=0.001). When focusing on patients with normal TSH levels, recurrence-free survivals after both the first and last sessions were significantly reduced in euthyroid patients with the highest quartile of TSH levels (quartile 4) compared with others (quartiles 1-3)....Continue Reading

References

Aug 1, 1972·The Journal of Clinical Investigation·P J Snyder, R D Utiger
Oct 31, 2001·American Heart Journal·J AuerB Eber
Nov 30, 2005·Archives of Internal Medicine·John P WalshValdo Michelangeli
Oct 10, 2007·Circulation·Irwin Klein, Sara Danzi
Apr 25, 2012·Archives of Internal Medicine·Tinh-Hai ColletUNKNOWN Thyroid Studies Collaboration
Sep 17, 2013·Circulation. Arrhythmia and Electrophysiology·Youhua ZhangA Martin Gerdes
Dec 18, 2013·American Heart Journal·Eun-Jeong KimJared W Magnani
Jul 25, 2014·The American Journal of Medicine·Helene BruereNicolas Clementy
Aug 22, 2015·Journal of the American College of Cardiology·Mikhail S DzeshkaEduard Shantsila
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Jan 4, 2017·European Journal of Internal Medicine·Alessandro P DelitalaGiuseppe Delitala
Apr 13, 2017·The New England Journal of Medicine·David J StottUNKNOWN TRUST Study Group
Oct 25, 2017·Circulation·Christine BaumgartnerUNKNOWN Thyroid Studies Collaboration

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Citations

Apr 25, 2020·International Journal of Molecular Sciences·Narcis TribulovaBarbara Szeiffova Bacova
Mar 12, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ryota YamauchiToyoaki Murohara
Jul 13, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Yan PeiYawei Xu
Aug 11, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichi FuruiToyoaki Murohara

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Methods Mentioned

BETA
sedation
coronary artery bypass

Software Mentioned

R

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