High NUSAP1 expression predicts poor prognosis in colon cancer.

Pathology, Research and Practice
Zhaoxiu LiuZhaolian Bian

Abstract

Nucleolar and spindle-associated protein 1 (NUSAP1) is an indispensable mitotic regulator. Aberrant NUSAP1 expression is associated with perturbed mitosis and tumorigenesis. In this study, we investigated the clinical significance of NUSAP1 expression in colon cancer. Immunohistochemical staining was performed to determine NUSAP1 protein levels in paraffin colon tumor specimens. Real-time fluorescent quantitative polymerase chain reaction (RT-qPCR) was conducted to detect NUSAP1 mRNA levels in colon tumor samples. The association between NUSAP1 protein expression and clinicopathological characteristics of patients with colon cancer was assessed. A Kaplan-Meier analysis was performed to determine the prognostic significance of NUSAP1 in colon cancer. A Cox proportional hazards model was used to calculate univariate and multivariate hazard ratios for the NUSAP1 and other clinicopathological variables. NUSAP1 protein and mRNA levels were significantly higher in colon tumor tissues than in paired non-cancerous adjacent tissues (P < 0.001, respectively). NUSAP1 protein expression was significantly correlated with histopathological grading (P < 0.001), depth of invasion (P = 0.001), lymph node metastasis (P < 0.001) and TNM stage (P ...Continue Reading

Citations

Feb 8, 2020·Journal of Cellular Biochemistry·Yuyang ZhangPengfei Jiang
Oct 23, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Meng ZhangQiang Wang
May 19, 2020·BioMed Research International·Yajun DengRuochen Zhao
Oct 8, 2020·Technology in Cancer Research & Treatment·Liqi LiDong Meng
Jan 26, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Pankaj AhluwaliaGagandeep K Gahlay
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rui LiangHong Ren
Mar 9, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Cong NieRong Lu

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