High on food: the interaction between the neural circuits for feeding and for reward

Frontiers in Biology
Jing-Jing LiuZhiping P Pang

Abstract

Hunger, mostly initiated by a deficiency in energy, induces food seeking and intake. However, the drive toward food is not only regulated by physiological needs, but is motivated by the pleasure derived from ingestion of food, in particular palatable foods. Therefore, feeding is viewed as an adaptive motivated behavior that involves integrated communication between homeostatic feeding circuits and reward circuits. The initiation and termination of a feeding episode are instructed by a variety of neuronal signals, and maladaptive plasticity in almost any component of the network may lead to the development of pathological eating disorders. In this review we will summarize the latest understanding of how the feeding circuits and reward circuits in the brain interact. We will emphasize communication between the hypothalamus and the mesolimbic dopamine system and highlight complexities, discrepancies, open questions and future directions for the field.

References

May 8, 1992·The Journal of Comparative Neurology·J C BittencourtP E Sawchenko
Oct 1, 1965·Journal of Comparative and Physiological Psychology·G Spies
Jul 1, 1982·Physiology & Behavior·R A FrankE S Valenstein
Jun 1, 1982·Behavioural Brain Research·D M AtrensG E Hunt
Jan 1, 1999·Nature·M ShimadaE Maratos-Flier
Dec 30, 1999·Science·S FultonP Shizgal
Feb 13, 2001·The Journal of Clinical Investigation·D S LudwigE Maratos-Flier
Feb 24, 2001·Lancet·G J WangJ S Fowler
Apr 3, 2001·Annual Review of Neuroscience·J T WillieM Yanagisawa
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Donald J MarshSu Qian
May 30, 2002·Neuroscience and Biobehavioral Reviews·Rudolf N CardinalBarry J Everitt
Oct 16, 2002·Journal of Psychosomatic Research·Susan A EversonGeorge A Kaplan
Oct 18, 2002·Neuron·Clifford B SaperJoel K Elmquist
May 3, 2003·Seminars in Clinical Neuropsychiatry·Dianne P Figlewicz
May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Huiyuan ZhengHans-Rudolf Berthoud
Aug 2, 2003·Biological Psychiatry·Dominique L MusselmanLawrence S Phillips
Sep 17, 2003·The Journal of Comparative Neurology·Diane L RosinPatrice G Guyenet
Nov 26, 1954·Science·P TEITELBAUM, E STELLAR
Dec 1, 1954·Journal of Comparative and Physiological Psychology·J OLDS, P MILNER
Nov 1, 1957·The American Journal of Physiology·S D MORRISON, J MAYER
Feb 2, 1962·Science·B G HOEBEL, P TEITELBAUM
Jun 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·B K ANAND, J R BROBECK
Mar 11, 2004·Appetite·Caroline DavisMarni Berkson

❮ Previous
Next ❯

Citations

Nov 12, 2019·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
May 18, 2021·The Journal of Clinical Investigation·Kristie B Yu, Elaine Y Hsiao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Carrie R FerrarioEoin C O'Connor
Acta Biologica Hungarica
L Lénárd, Z Karádi
Reviews in Endocrine & Metabolic Disorders
Liangyou Rui
Clinical Neuropharmacology
H C FibigerG Damsma
Advances in Neurobiology
Paulo Matafome, Raquel Seiça
© 2022 Meta ULC. All rights reserved