PMID: 2496102May 1, 1989Paper

High osmolarity is a signal for enhanced algD transcription in mucoid and nonmucoid Pseudomonas aeruginosa strains

Journal of Bacteriology
A BerryA M Chakrabarty

Abstract

Chronic lung infection with mucoid, alginate-producing strains of Pseudomonas aeruginosa is a major cause of mortality in cystic fibrosis (CF) patients. Transcriptional activation of the P. aeruginosa algD gene, which encodes GDPmannose dehydrogenase, is essential for alginate synthesis. Activation of algD is dependent on the product of the algR gene. Sequence homology between the P. aeruginosa algR gene and the Escherichia coli ompR gene, which regulates the cellular response to changes in osmolarity of the growth medium, together with the abnormally high levels of Na+ and Cl- in respiratory tract fluid in CF patients suggested that high osmolarity in the lung of the CF patient might be a signal contributing to the induction of alginate synthesis (mucoidy) in infecting P. aeruginosa. In both mucoid and nonmucoid P. aeruginosa strains (containing a functional algR gene), transcriptional activation of algD increased as the osmolarity of the culture medium increased. The increased activation of algD at high osmolarity was not in itself sufficient to induce alginate synthesis in nonmucoid strains, however, suggesting that other environmental factors are involved in full activation of the alginate genes. The targets of AlgR and Omp...Continue Reading

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Citations

Mar 15, 1997·FEMS Microbiology Letters·J F MaD J Hassett
Jun 27, 2012·Environmental Microbiology·Olaya RenduelesJean-Marc Ghigo
Jul 1, 1993·World Journal of Microbiology & Biotechnology·J L Ramos, S Marqués
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Feb 13, 2001·Microbiology·I Sutherland
Jul 25, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Vinicius Vicente MartinsEliana Guedes Stehling
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Jun 1, 1990·Journal of Clinical Microbiology·M FeganJ A Fuerst

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