High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives

Journal of Controlled Release : Official Journal of the Controlled Release Society
Suyeon YouYoonkyung Kim

Abstract

The use of computed tomography (CT) for vascular imaging is critical in medical emergencies requiring urgent diagnostic decisions, such as cerebral ischemia and many cardiovascular diseases. Small-molecule iodinated contrast media are often injected intravenously as radiopaque agents during CT imaging to achieve high contrast enhancement of vascular systems. The rapid excretion rate of these agents is overcome by injecting a significantly high dose of iodine, which can have serious side effects. Here we report a simple method to prepare blood-pool contrast agents for CT based on dendrimers for the first time using tetraiodobenzene derivatives as potent radiopaque moieties. Excellent in vivo safety has been demonstrated for these small (13-22nm) unimolecular water-soluble dendritic contrast agents, which exhibit high contrast enhancement in the blood-pool and effectively extend their blood half-lives. Our method is applicable to virtually any scaffold with suitable surface groups and may fulfill the current need for safer, next-generation iodinated CT contrast agents.

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Citations

Dec 23, 2017·Contrast Media & Molecular Imaging·Justin J TseDavid W Holdsworth
Mar 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Christos TapeinosGianni Ciofani
Aug 21, 2019·Anti-cancer Agents in Medicinal Chemistry·Paromita KunduSanjeeb K Sahoo
Sep 16, 2018·Scientific Reports·James F HainfeldHenry M Smilowitz
Mar 22, 2021·International Journal of Pharmaceutics·Vikrant SalujaPallavi Nayak
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nina FilipczakVladimir Torchilin
May 8, 2019·ACS Applied Materials & Interfaces·Jinsong CaoZhiyuan Zhong
Sep 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K R Sneha, G S Sailaja

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