High-performance liquid chromatographic analyses of the antihypertensive drug captopril

Journal of Chromatography
S Perlman, J Kirschbaum

Abstract

High-performance liquid chromatographic systems have been developed to separate and quantitate captopril. The presence of interfering excipients in various formulations necessitated the development of three assays, each with distinctly different columns and mobile phases. All work well for bulk material, providing short analysis time, high precision, and rapid sample preparation, demonstrating that there is not necessarily one, best, high-performance liquid chromatographic system. The advantages and shortcomings of the ion-exchange, amino and octadecylsilane systems are evaluated and one of them is selected as optimum for bulk and tablet analysis.

Citations

Jul 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·F M DuncanC R Edwards
Jan 1, 1985·Journal of Pharmaceutical and Biomedical Analysis·W F Heyes, M L Robinson
Mar 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·T JovanovićZ Korićanac
May 16, 1990·Journal of Chromatography·J KirschbaumJ Adamovics
Nov 5, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takashi NishikawaKayoko Tahara
May 19, 2005·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Sarah D PressmanJohn J Treanor
May 1, 1984·Journal of Pharmaceutical Sciences·J Kirschbaum, S Perlman
Apr 1, 1989·Journal of Applied Toxicology : JAT·G TruchonM Gérin

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