PMID: 6403694Feb 1, 1983Paper

High-performance liquid chromatographic assay for partially nitrated glycerins in nitroglycerin

Journal of Pharmaceutical Sciences
D M BaaskeJ E Carter

Abstract

A high-performance liquid chromatographic method for determining the concentration of mononitroglycerins and dinitroglycerins in the commonly used pharmaceutical raw material nitroglycerin (10% w/w) on lactose USP is presented. A coefficient of variation of less than 5% for the partially nitrated glycerins was achieved over the range examined (0-4.0 micrograms/mg). Thirteen lots of raw material were examined and found to contain a total of less than 0.13% w/w partially nitrated glycerins. A variable wavelength detector (lambda = 218 nm) and a microphenyl column were employed. The mobile phase was acetonitrile-water (36:64) pumped at 2 ml/min. The internal standard was isosorbide dinitrate. Total analysis time was 12 min.

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Citations

Jul 1, 1985·Biopharmaceutics & Drug Disposition·S H Curry, S M Aburawi
Nov 1, 1987·British Journal of Orthodontics·N E Carter
Jul 1, 1985·Drug Intelligence & Clinical Pharmacy·D E SchaberH G McCoy

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