High-performance liquid chromatographic method for the rapid and simultaneous determination of sulfamonomethoxine, miloxacin and oxolinic acid in serum and muscle of cultured fish

Journal of Chromatography. B, Biomedical Applications
R Ueno, T Aoki

Abstract

A rapid method for the simultaneous determination of sulfamonomethoxine (SMM), miloxacin (MLX) and oxolinic acid (OA) in serum and muscle of cultured fish by high-performance liquid chromatography has been developed. A Hisep shielded hydrophobic phase column (15 cm x 4.6 mm I.D.) and a mobile phase of 0.05 M citric acid-0.2 M disodium hydrogenphosphate buffer, pH 2.5 in 10 mM tetra-n-butyl ammonium bromide-acetonitrile (85:15) with ultraviolet detection at 265 nm were used. The recoveries of SMM, MLX and OA from serum and muscle samples were 72-101%. The detection limits of the three drugs were 0.05-0.1 microgram/ml or g of sample.

References

Nov 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H V Björklund, G Bylund

Citations

Jan 31, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·S SouverainJ-L Veuthey
Mar 10, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·M TourakiC Prokopiou
Mar 19, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·G ZhangQ Liu
Feb 28, 2002·Journal of Chromatography. a·J A Hernández-ArteserosM D Prat

Related Concepts

AB 206
Metazoa
Microbicides
High Pressure Liquid Chromatography Procedure
Drug Residues
Eels
Fisheries
Food Contamination
Muscle
Sodium Oxolinate

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