PMID: 8952453Nov 1, 1996Paper

High-performance liquid chromatographic methods for determination of marine biotoxins

The Analyst
M Comesaña-LosadaJ A Rodríguez-Vázquez

Abstract

Paralysing and diarrhetic shellfish poisonings (PSP and DSP) are important intoxications caused by the consumption of shellfish, mainly bivalve molluscs, contaminated by certain species of toxic dinoflagellates present in the marine phytoplankton. Their appearance and massive reproduction take place in some periods of the year, causing the phenomenon commonly known as 'red tide'. This causes significant problems to health and to the economy of the Galician region. The AOAC mouse bioassay is the most commonly used method of analysis for these toxic compounds, being the official method in most countries. Owing to the lack of sensitivity and selectivity of the biological assay, HPLC methods were developed as an alternative methodology. In this paper work carried out on the improvement of the chromatographic conditions in order to achieve accurate information about the PSP and DSP compounds present in the studied samples is reported.

References

Mar 1, 1978·Analytical Biochemistry·L J BuckleyY Shimizu
Mar 1, 1975·Journal of Agricultural and Food Chemistry·H A Bates, H Rapoport
Oct 30, 1992·Journal of Chromatography·B Luckas
Mar 1, 1990·Trends in Biochemical Sciences·P CohenY Tsukitani
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SuganumaT Sugimura
Nov 28, 1980·Biochemical and Biophysical Research Communications·S HallR A Neve

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