High-performance liquid chromatographic enantioseparations on capillary columns containing monolithic silica modified with cellulose tris(3,5-dimethylphenylcarbamate)

Journal of Separation Science
Bezhan ChankvetadzeYoshio Okamoto

Abstract

Monolithic capillary columns containing native silica gel were modified with cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) and used for enantioseparations in capillary liquid chromatography. The method adopted for in situ enantioselective modification of monolithic fused silica capillary columns by coating with CDPMC appears to be fairly simple and fast. High efficiency enantioseparations of test racemic compounds and s(everal chiral drugs were achieved in a short time. It was possible to increase the amount of chiral selector present by multiple coating of monoliths with CDMPC. The baseline enantioseparation of 2,2,2-trifluoro-1-(9-anthryl)ethanol was achieved in an analysis time less than 30 s with this capillary column. In addition, reproducible enantioseparations were obtained when the chiral selector was removed from the monolithic column by flushing it with appropriate solvent and the column recoated.

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Citations

May 17, 2005·Analytical and Bioanalytical Chemistry·Michael Lämmerhofer
May 3, 2014·Journal of Pharmaceutical and Biomedical Analysis·Zeineb AturkiSalvatore Fanali
Jun 29, 2010·Journal of Pharmaceutical and Biomedical Analysis·Michael Lämmerhofer, Andrea Gargano
Jun 17, 2016·Annual Review of Analytical Chemistry·Tohru Ikegami, Nobuo Tanaka
Oct 22, 2016·Journal of Chromatography. a·Salvatore Fanali
Feb 1, 2018·Journal of Separation Science·Romina Noel EchevarriaJosé Manuel Herrero-Martinez
Aug 2, 2017·Electrophoresis
Aug 10, 2006·Journal of Separation Science·Feng QinHanfa Zou
Jul 12, 2007·Journal of Separation Science·Javier Hernández-BorgesSalvatore Fanali
Dec 4, 2008·Journal of Separation Science·Michael D SlaterFrantisek Svec
Feb 20, 2010·Journal of Separation Science·Bezhan Chankvetadze
Oct 19, 2010·Biomedical Chromatography : BMC·Elfriede Pittler, Martin G Schmid
Jun 9, 2006·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroshi KobayashiNobuo Tanaka
Jan 8, 2013·Journal of Separation Science·Anna RoccoSalvatore Fanali
Jul 25, 2013·Journal of Chromatography. a·Chiara FanaliAnna Rocco

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