PMID: 7014830Apr 1, 1981Paper

High-performance liquid chromatographic determination of ethmozin in plasma

Journal of Pharmaceutical Sciences
C C WhitneyJ C Gaylord

Abstract

A sensitive, specific high-performance liquid chromatographic procedure was developed for the determination of plasma ethmozin levels. Basic plasma samples were partitioned with methylene chloride. The organic extract was washed with water and then evaporated to dryness under reduced pressure. The residue was redissolved in 0.2 ml of the mobile phase, consisting of hexane-tetrahydrofuran-methanol-water (66:27:6,30:0.7 v/v), and then chromatographed on a microporous silica column. With a variable-wavelength UV detector set at 268 nm, 10 ng of ethmozin/ml of plasma was measured. The utility of the method for human pharmacokinetic studies was demonstrated.

Citations

Mar 1, 1991·Journal of Clinical Pharmacology·I H BenedekH J Pieniaszek
May 11, 1992·Journal of Clinical Pharmacology·H J PieniaszekU F Michael
Jul 1, 1994·Journal of Clinical Pharmacology·E G GiardinaR Sciacca
Feb 1, 1994·Journal of Clinical Pharmacology·I H BenedekH J Pieniaszek
Oct 1, 1995·Journal of Clinical Pharmacology·P J RiceA V Mehta
Dec 1, 1996·Journal of Clinical Pharmacology·L ShumW Flamenbaum
Jan 1, 1987·European Journal of Clinical Pharmacology·D L HowrieL W Dittert
Jun 1, 1991·Journal of the American College of Cardiology·M E WechslerE G Giardina
Jun 11, 1992·Journal of Clinical Pharmacology·I H BenedekH J Pieniaszek
Mar 1, 1985·Journal of Clinical Pharmacology·R T MacFarlandF I Marcus
Apr 1, 1994·Biopharmaceutics & Drug Disposition·H J PieniaszekM Mayersohn

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