High-performance liquid chromatographic separation and isolation of quinidine and quinine metabolites in rat urine

Journal of Chromatography
S E BarrowM G Horning

Abstract

A procedure for the separation and isolation of the urinary metabolites of quinidine and quinine by reversed-phase high-performance liquid chromatography is described. Nine metabolites of quinidine and eight metabolites of quinine were detected in the urine of male Sprague-Dawley rats after a single dose of quinidine or quinine (50 mg kg-1). Following extraction from urine, the metabolites were separated on either an analytical or a semi-preparative reversed-phase column by gradient elution. After isolation and derivatization, the metabolites were analyzed by gas chromatography and gas chromatography--mass spectrometry.

References

Jan 1, 1979·Journal of Chromatography·T W GuentertS Riegelman
Mar 11, 1976·Archives of Toxicology·J JovanovićG Spiteller
Jul 1, 1973·Journal of Pharmaceutical Sciences·E SmithJ Levine
Aug 1, 1969·Biochemical Pharmacology·K H PalmerM E Wall

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Citations

Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·T W GuentertS Riegelman
Oct 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·C BeedhamD J Rance
Apr 25, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·R A MirghaniL L Gustafsson
Jul 8, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·R A MirghaniL L Gustafsson
Oct 10, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·M IglarzR Farinotti
Oct 29, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·P BannonJ P Villeneuve
Feb 1, 1991·British Journal of Clinical Pharmacology·S WanwimolrukA Oranratnachai
Jan 1, 1990·The Journal of Pharmacy and Pharmacology·M D ColemanL Fleckenstein
Sep 1, 1986·British Journal of Clinical Pharmacology·S WanwimolrukP Patamasucon
Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O O BolajiP A Dixon
Oct 1, 1984·Journal of Pharmacokinetics and Biopharmaceutics·A RakhitS Riegelman
Feb 22, 1985·Journal of Chromatography·J C ReijengaF M Everaerts
May 10, 1985·Journal of Chromatography·V SchwarzK Macek

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