High-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry for the analysis of 1,2,3,4-tetrahydro-beta-carboline derivatives

Journal of Chromatography. a
B Gutsche, M Herderich

Abstract

A rapid and sensitive method is described for the detection of 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, 1-methyl-1,2,3,4- tetrahydro-beta-carboline-3-carboxylic acid and 1-methyl-1,2,3,4-tetrahydro-beta-carboline by electrospray ionization tandem mass spectrometry coupled to liquid chromatography. In combination with selected reaction monitoring (SRM) detection limits of 3 ng ml-1 (ca. 75 fmol on column) were established by the use of model solutions. Due to the excellent selectivity and sensitivity of SRM no sample preparation step was required prior to analysis of food samples. In addition, any artifactual formation of tetrahydro-beta-carbolines could be excluded. Application of the method revealed that all food samples analyzed contained both tetrahydro-beta-carboline-carboxylic acids at ng ml-1 to microgram ml-1 concentrations, whereas 1-methyl-1,2,3,4-tetrahydro- beta-carboline was identified in most samples as a minor constituent.

References

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Aug 1, 1995·Alcoholism, Clinical and Experimental Research·C D SpiesL Hannemann
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Citations

Aug 15, 2009·Rapid Communications in Mass Spectrometry : RCM·B RajuR Srinivas
Feb 18, 2006·The Journal of Nutrition·Makoto IchikawaKazuhisa Ono
Oct 29, 2014·Expert Review of Proteomics·Robert Harlan, Hui Zhang
Sep 11, 2020·Free Radical Biology & Medicine·Stephanie BellmaineAline Zimmer
Oct 29, 2000·Journal of Agricultural and Food Chemistry·T Herraiz

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