High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma.

International Journal of Clinical Oncology
Richard SalzmanRom Kostřica

Abstract

The aim of the study was to investigate the relationships among (a) glutathione peroxidase (GPx) and malondialdehyde (MDA); (b) oncological characteristics (i.e., TNM classification, tumor grade), and; (c) prognosis of head and neck squamous cell carcinoma. In a prospective cohort study, we followed 88 patients for 67.4 months (median 40.3) after surgery for head and neck squamous cell carcinoma. Activity of GPx was determined by ELISA and plasma MDA concentration by liquid chromatography. Lower GPx activity was observed in the T3/4 patients than in the T1/2 group. Tumor grade was significantly correlated with both GPx (P = 0.001) and MDA (P = 0.05, both Spearman). The perioperative level of MDA was higher in patients who later recurred during the follow-up period (n = 15) than in the complete remission group (P = 0.01, Mann-Whitney). Median disease-free interval and overall survival in the group with MDA > median were 29.5 and 32.0 months, respectively, and 38.4 and 40.3 months in the patient group with MDA ≤ median (P = 0.10 and P = 0.08, respectively; Kaplan-Meier). Patients with MDA levels higher than the median had a more than twofold greater risk of recurrence than patients with MDA levels smaller than the median (31.3 vs...Continue Reading

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Citations

Sep 13, 2013·BioMed Research International·Amruta MankeYon Rojanasakul
Dec 6, 2012·Experimental Hematology & Oncology·Pekka PerojaPeeter Karihtala
Oct 3, 2013·PloS One·Takuma InuiHidetoshi Okabe
Mar 17, 2015·Cancer Letters·Sara Santos BernardesAlessandra Lourenço Cecchini
Feb 8, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ahmet Aksoy, Senem Çengel Kurnaz
Feb 15, 2020·Medicina·Janina DidžiapetrienėValerijus Ostapenko
May 26, 2017·Frontiers in Oncology·Didier DequanterSandra Nuyts

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