High plasma levels of a ouabain-like factor in normal pregnancy and in pre-eclampsia

European Journal of Clinical Investigation
P DelvaA Lechi

Abstract

Recent reports have described high levels of one or more substances which cross-react with digoxin antibodies in the serum of women with pre-eclampsia. We measured plasma ouabain-like activity and intraerythrocyte sodium and potassium concentrations, in addition to performing routine hypertensive laboratory tests, in 13 normotensive non-pregnant subjects, 15 normotensive pregnant women and 16 pre-eclamptic women (gestational age: 33-36 weeks). Plasma ouabain-like activity, measured as plasma-induced variations in ouabain binding to human erythrocytes, proved significantly higher in both groups of pregnant subjects as compared to normotensive non-pregnant women, and a significant difference was also found between pre-eclamptic and normotensive pregnant women, the former exhibiting higher plasma ouabain-like activity. No differences in intracellular sodium and potassium levels were detected among the three groups studied. Though there is reason to believe that the high plasma levels found both in normal and hypertensive pregnancy may depend on placental production, we are not in a position to define with any degree of certainty what the mechanism or mechanisms are that regulate ouabain-like factor production.

References

Sep 4, 1976·Lancet·F H DerkxM A Schalekamp
Jan 1, 1977·American Journal of Obstetrics and Gynecology·B R KuhnertR J Sokol
Jun 1, 1973·The Journal of Physiology·R P Garay, P J Garrahan
Oct 1, 1984·Journal of Hypertension·B F Robinson
Jan 1, 1984·Journal of Cardiovascular Pharmacology·F J Haddy, M B Pamnani
Sep 10, 1983·British Medical Journal·P L WeissbergD G Beevers
Sep 1, 1984·American Journal of Obstetrics and Gynecology·J P GusdonJ F Hennessy
Jul 31, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Rubython, D B Morgan
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·S W GravesH R Craig
Mar 14, 1981·British Medical Journal·L PostonH E de Wardener
Apr 11, 1981·British Medical Journal·J G KellyK O'Malley

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Citations

Aug 16, 1991·European Journal of Pharmacology·J MarínC F Sánchez-Ferrer
Oct 20, 1992·European Journal of Pharmacology·M S Fernández-AlfonsoJ Marín
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Iva Dostanic-LarsonJerry B Lingrel
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jack H Kaplan
Jun 3, 1998·American Journal of Obstetrics and Gynecology·M Glavind-KristensenA Forman
May 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jessica Venugopal, Gustavo Blanco
Jul 28, 2016·Hypertension·John M Hamlyn, Mordecai P Blaustein

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