High plasma norepinephrine attenuates the dynamic heart rate response to vagal stimulation

American Journal of Physiology. Heart and Circulatory Physiology
Tadayoshi MiyamotoK Sunagawa

Abstract

To better understand the pathophysiological significance of high plasma norepinephrine (NE) concentration in regulating heart rate (HR), we examined the interactions between high plasma NE and dynamic vagal control of HR. In anesthetized rabbits with sinoaortic denervation and vagotomy, using a binary white noise sequence (0-10 Hz) for 10 min, we stimulated the right vagus and estimated the transfer function from vagal stimulation to HR response. The transfer function approximated a first-order low-pass filter with pure delay. Infusion of NE (100 microg. kg(-1) x h(-1) iv) attenuated the dynamic gain from 6.2 +/- 0.8 to 3.9 +/- 1.2 beats x min(-1) x Hz(-1) (n = 7, P < 0.05) without affecting the corner frequency or pure delay. Simultaneous intravenous administration of phentolamine (1 mg x kg(-1) x h(-1)) and NE (100 microg x kg(-1) x h(-1)) abolished the inhibitory effect of NE on the dynamic gain (6.3 +/- 0.8 vs. 6.4 +/- 1.3 beats x min(-1) x Hz(-1), not significant, n = 7). The inhibitory effect of NE at infusion rates of 10, 50, and 100 microg x kg(-1) x h(-1) on dynamic vagal control of HR was dose-dependent (n = 5). In conclusion, high plasma NE attenuated the dynamic HR response to vagal stimulation, probably via activat...Continue Reading

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Citations

Dec 8, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoDonal S O'Leary
Nov 15, 2008·European Journal of Applied Physiology·M BuchheitS Ahmaidi
Nov 3, 2009·European Journal of Applied Physiology·Hani Al HaddadMartin Buchheit
Sep 18, 2012·European Journal of Applied Physiology·Konstantina DiplaIoannis S Vrabas
Apr 21, 2010·Autonomic Neuroscience : Basic & Clinical·Hani Al HaddadMartin Buchheit
Apr 28, 2009·Experimental Physiology·M BuchheitS Ahmaidi
Feb 7, 2013·Clinical Physiology and Functional Imaging·Tiago Peçanha de OliveiraJorge Roberto Perrout de Lima
Dec 24, 2014·Clinical Physiology and Functional Imaging·Osung KwonYou-Ho Kim
Jun 1, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Scott MichaelGlen M Davis
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Tadayoshi MiyamotoKenji Sunagawa
Dec 17, 2008·American Journal of Physiology. Heart and Circulatory Physiology·M BuchheitP B Laursen
Apr 13, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Martin BuchheitSébastien Ratel
Mar 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Martin BuchheitSaïd Ahmaidi
May 29, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Masaki MizunoMasaru Sugimachi
Dec 6, 2008·Journal of Strength and Conditioning Research·Martin BuchheitSaid Ahmaidi
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
Jul 14, 2017·European Journal of Applied Physiology·Scott MichaelGlen M Davis
Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoFerdinando Iellamo
Aug 3, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Masashi IchinoseDonal S O'Leary

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