High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes

International Journal of Obesity : Journal of the International Association for the Study of Obesity
C HuboldAchim Peters

Abstract

Vascular endothelial growth factor (VEGF) has been suggested to enhance glucose transport across the blood-brain barrier, thereby increasing brain glucose supply. Increased brain glucose concentration is known to suppress food intake and to decrease body mass via action on hypothalamic regulation centers. Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans. Intending to investigate subjects with high variance of blood glucose, we examined patients with type 2 diabetes mellitus. Our hypothesis was tested in a population-based cohort of 190 subjects with type 2 diabetes. Plasma VEGF levels in conjunction with other parameters known to modulate food intake were measured and subsequently correlated with food intake patterns at a breakfast buffet as well as with body mass. We found that subjects with higher concentrations of plasma VEGF had 17% less carbohydrate intake (P=0.003) and 4.8% lower body mass (P=0.017) than those with lower VEGF concentrations. Intake of protein and fat did not correlate with VEGF concentrations. These associations of plasma VEGF were confirmed in multiple linear regression analyses control...Continue Reading

References

Jan 1, 1975·Journal of Medical Primatology·C L Hamilton, D Lewis
Nov 1, 1975·The American Journal of Physiology·R R Miselis, A N Epstein
Jan 1, 1992·The Journal of Clinical Investigation·L B JakemanN Ferrara
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Apr 21, 1967·Science·J Mayer, D W Thomas
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P AielloL E Smith
Mar 21, 1998·Metabolism: Clinical and Experimental·H A GielkensA A Masclee
Feb 23, 1999·The American Journal of Pathology·A RivardJ M Isner
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·An S DE VrieseNorbert H Lameire
May 9, 2001·The Journal of Clinical Investigation·P SchratzbergerJ M Isner
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Dorle DantzAchim Peters
Jul 31, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A PetersH L Fehm
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Ali H MokdadJames S Marks
Dec 10, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nina ManiJeffrey M Rosenstein
Jun 3, 2004·Neuroscience and Biobehavioral Reviews·A PetersH L Fehm
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luc Leybaert

❮ Previous
Next ❯

Citations

Dec 1, 2009·International Journal of Endocrinology·Andre SchmollerKerstin M Oltmanns
Jun 23, 2010·European Journal of Endocrinology·P L KristensenB Thorsteinsson
Dec 15, 2007·Metabolism: Clinical and Experimental·Kerstin M OltmannsAchim Peters
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Neuroscience and Biobehavioral Reviews
A PetersH L Fehm
American Journal of Physiology. Endocrinology and Metabolism
Kerstin M OltmannsAchim Peters
© 2021 Meta ULC. All rights reserved