High Plasmodium Infection Rate and Reduced Bed Net Efficacy in Multiple Insecticide-Resistant Malaria Vectors in Kinshasa, Democratic Republic of Congo

The Journal of Infectious Diseases
Jacob M RiveronCharles S Wondji

Abstract

Accounting for approximately 11% of all malaria cases, the Democratic Republic of the Congo (DRC) is central to malaria elimination efforts. To support vector control interventions in DRC, we characterized the dynamics and impact of insecticide resistance in major malaria vectors in 2015. High Plasmodium infection rates were recorded in Anopheles gambiae and Anopheles funestus, with Plasmodium falciparum predominant over Plasmodium malariae. Both mosquito species exhibited high and multiple resistance to major public health insecticide classes. The extremely high resistance to permethrin and DDT (dichlorodiphenyltrichloroethane) in An. gambiae (low mortalities after 6 hours exposure) is worrisome, and is supported by a reduced insecticidal effect of bed nets against both mosquito species in laboratory tests. Metabolic and target site insensitivity mechanisms are driving this resistance in An. gambiae, but only the former was observed in An. funestus. These findings highlight the urgent need for actions to prolong the effectiveness of insecticide-based interventions in DRC.

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Citations

Oct 28, 2019·Parasites & Vectors·Christophe Antonio-NkondjioCharles S Wondji
Dec 5, 2019·Infectious Diseases of Poverty·Sulaiman S IbrahimCharles S Wondji
Sep 12, 2020·Parasites & Vectors·Eunice Oluwatobiloba AdedejiEzekiel Adebiyi
Dec 13, 2018·Wellcome Open Research·Claire L JeffriesThomas Walker
Feb 3, 2021·Parasite : Journal De La Société Française De Parasitologie·Roland BamouChristophe Antonio-Nkondjio

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