High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Tong-Chun XueYan-Hong Wang

Abstract

Accumulating evidence suggests platelets play critical roles in tumor metastasis. Moreover, the role of platelets in metastasis is partially correlated with inflammation. However, evidence regarding the contribution of platelets to hepatocellular carcinoma (HCC) metastasis is lacking. This study investigated the association between platelets and metastatic risk in HCC. We used huge HCC (diameter over 10 cm), a tumor subgroup with a strong inflammatory background, as a model to evaluate the potential predictive role of platelets and platelet-related biomarkers for metastasis in HCC patients undergoing transarterial chemoembolization. A logistic regression model was used to analyze risk factors for metastasis. Patients with huge HCC (n = 178) were enrolled, and 24.7% (44/178) of patients had remote metastases after treatment. Univariate analyses showed high platelet counts (P = 0.012), pretreatment platelet-to-lymphocyte ratios (pre-PLR) of 100 or more (P = 0.018) and post-PLR of 100 or more (P = 0.013) were potential risk factors for metastasis. Furthermore, multivariate analyses showed high platelet counts (odds ratio, 2.18; 95% confidence interval, 1.074-4.443; P = 0.031) and platelet-related biomarkers were independent risk f...Continue Reading

References

Dec 20, 2003·Journal of Cancer Research and Clinical Oncology·Zhao-You TangKang-Da Liu
Nov 21, 2007·Thrombosis Research·Joseph S Palumbo, Jay L Degen
Dec 14, 2007·The New England Journal of Medicine·Giovanni Davì, Carlo Patrono
Jan 25, 2011·Nature Reviews. Cancer·Laurie J Gay, Brunhilde Felding-Habermann
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 6, 2011·Journal of Surgical Oncology·Yo-ichi YamashitaYoshihiko Maehara
Feb 18, 2012·The New England Journal of Medicine·Rebecca L StoneAnil K Sood
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Giovanni SitiaLuca G Guidotti
Aug 21, 2012·Journal of Surgical Oncology·Shun-Ichi AriizumiMasakazu Yamamoto
Dec 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yan WuLimin Zheng
Jan 15, 2013·Gastroenterology·Virginia Hernandez-GeaJosep M Llovet
Feb 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Riccardo Lencioni
Jun 8, 2013·Journal of Hepatology·Giovanni SitiaLuca G Guidotti
Aug 10, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lulu LiuXin-Yuan Guan
Dec 7, 2013·Hämostaseologie·J RiedlC Ay
Feb 21, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuki MorimotoKazuhide Yamamoto
May 6, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Arnoud J TempletonEitan Amir
Nov 21, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X XieJ Chen

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Citations

Dec 22, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takayoshi KaidaHideo Baba
Nov 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jei-Ming PengSen-Yung Hsieh
Jan 10, 2020·Science Translational Medicine·Alessandra MetelliZihai Li
Sep 13, 2019·Cell Death and Differentiation·Ruo-Yu ChenLiang-Yi Hung
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Pierluigi RamadoriMathias Heikenwalder

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