High platelet reactivity is associated with myocardial infarction in premenopausal women: a population-based case-control study

Journal of Thrombosis and Haemostasis : JTH
J D SnoepJ G Van Der Bom

Abstract

Platelets are involved in the occlusion of coronary arteries after rupture of an atherosclerotic plaque. Furthermore, activated platelets release large quantities of growth factors, chemokines and interleukins that regulate inflammatory reactions. Therefore, we hypothesized that high basal platelet reactivity may contribute to an increased risk of myocardial infarction (MI) in premenopausal women. We assessed the relation between high platelet reactivity and MI in a population-based case-control study among premenopausal women (aged < 50 years). We used multivariable logistic regression to quantify the effect of high platelet reactivity, adjusted for potential confounders. Platelet reactivity was estimated by plasma levels of neutrophil activating peptide 2 (NAP-2), CXC chemokine ligand (CXCL)4, soluble glycoprotein 1b (sGPIb) and soluble P-selectin. High platelet reactivity (i.e. levels >or= 90th percentile control subjects) was associated with a 2- to 3-fold increased incidence of MI: the adjusted odds ratios (ORs) were 3.0 [95% confidence interval (CI) 1.4-6.4] for NAP-2, 2.2 (0.9-5.1) for CXCL4, 1.9 (0.7-4.6) for sP-selectin and 2.5 (1.1-5.7) for sGPIb. The incidence of MI dose-dependently increased when more markers were e...Continue Reading

Citations

May 13, 2011·Journal of Thrombosis and Thrombolysis·Gaurav Sharma, Jeffrey S Berger
Aug 27, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Imo E HoeferGerard Pasterkamp
Dec 1, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sheng-Yong DongLi-Hua Ma
May 11, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·A TuinenburgR E G Schutgens
Mar 1, 2011·Journal of Thrombosis and Haemostasis : JTH·M J HollestelleV E A Gerdes
Sep 14, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·E R van BladelR E G Schutgens
Oct 20, 2010·British Journal of Haematology·David JiménezRoger D Yusen

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