High potassium diets markedly protect against stroke deaths and kidney disease in hypertensive rats, a possible legacy from prehistoric times

Canadian Journal of Physiology and Pharmacology
L Tobian

Abstract

Male spontaneously hypertensive stroke-prone (SHRsp) rats were fed 4% NaCl diets containing either 0.75% (normal) K or 2.11% (high) K, starting at 6 weeks of age. After 8 months on these diets, 40 out of 58 SHRsp rats on the 0.75% K diet had died (69% mortality) versus 2 dead out of 95 on the 2.11% K diet (2% mortality), a 97% reduction in mortality, p less than 0.00001. After 20 weeks on the diets, the daytime and nighttime blood pressures of each rat were measured intraarterially under light ether anesthesia. Using these accurate blood pressures, we selected two groups precisely matched for blood pressure. One matched SHRsp group (BP 182) ate the 0.75% K diet and 30 out of 47 rats died (64% mortality). The other matched SHRsp group (BP 182) ate the 2.11% K diet and 2 out of 35 died (6% mortality), a 91% reduction of mortality, p less than 0.0001. Seemingly, this striking reduction in mortality rate with the 2.11% high K diet does not depend on a lowering of blood pressure. High K diets do not change body Na or K. Dry weight of mesenteric arterioles was reduced 29% on the 2.11% K diet versus the 0.75% K diet (5.43 vs. 7.66 mg) (p less than 0.0001), indicating a greatly reduced hypertensive hypertrophy. In nine surviving SHRsp ...Continue Reading

References

Jan 31, 1985·The New England Journal of Medicine·S B Eaton, M Konner
May 1, 1983·Annals of Internal Medicine·H G Langford
May 27, 1982·The New England Journal of Medicine·S G RostandB A Pate

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Citations

Mar 16, 2011·Current Hypertension Reports·Mark C Houston
May 1, 1994·General Pharmacology·G FroldiG Fassina
Mar 27, 2004·European Journal of Pharmacology·Shuichi TsuruokaAkio Fujimura
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·M TanakaR C Morris
Sep 5, 2001·BMJ : British Medical Journal·F J He, G A MacGregor
Jun 5, 2002·The Journal of Clinical Hypertension·D A SicaM Epstein
Mar 1, 1990·Cardiovascular Drugs and Therapy·H G Langford, R L Watson
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·J G Fodor, A Chockalingam
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·L J Beilin
Dec 14, 1987·The American Journal of Cardiology·L Tobian
Mar 3, 1999·Medical Hypotheses·M F McCarty
Aug 13, 1999·Progress in Cardiovascular Diseases·D A McCarron, M E Reusser
Nov 1, 1988·The American Journal of Medicine·M P SambhiH M Perry
Feb 1, 1990·Hypertension·R Di NicolantonioT O Morgan
Sep 2, 1999·Stroke; a Journal of Cerebral Circulation·H IsoW C Willett
Apr 1, 1992·Stroke; a Journal of Cerebral Circulation·J D Peuler, R L Schelper
May 24, 2020·Clinical Cardiology·Amina RakishevaPanos Vardas
Jul 1, 1997·Canadian Journal of Physiology and Pharmacology·J S Smeda
Apr 14, 1988·The New England Journal of Medicine·C N LeeD Chiu

❮ Previous
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