High-precision piezo-ejection ocular microdosing: Phase II study on local and systemic effects of topical phenylephrine

Therapeutic Delivery
Tsontcho IanchulevLouis Pasquale

Abstract

Conventional eyedropper-delivered volumes (25-50 µl) exceed the eye's usual tear-film volume (7 µl) and precorneal reservoir capacity, risking overflow and ocular/systemic complications. Piezoelectric high-precision microdosing may circumvent these limitations. Results & methodology: In this masked, nonrandomized, cross-over study, subjects (n = 12) underwent pupil dilation with topical phenylephrine (PE) administered by 32-µl eyedropper (2.5% or 10% formulation) and 8-µl electronic microdosing (10% formulation). Microdosing with PE-10% achieved comparable peak dilation as 10% eyedropper-delivery and superior dilation to 2.5% eyedropper-delivery (p = 0.009) at 75 min. Microdosing significantly reduced 20-min plasma PE levels versus PE10% eyedropper; neither treatment altered heart rate/blood pressure. Eye irritation occurred significantly less frequently with microdosing than PE10% eyedrops. Piezo-ejection PE microdosing achieves comparable biological effect as eyedropper dosing; reduced systemic absorption may decrease risk of systemic side effects.

References

Jan 1, 1974·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·W ScherzC H Dohlman
Mar 1, 1974·Journal of Pharmaceutical Sciences·S S ChraiJ R Robinson
Aug 1, 1984·Archives of Ophthalmology·G PeturssonC Hanna
May 1, 1993·Survey of Ophthalmology·A Urtti, L Salminen
Mar 15, 1993·American Journal of Ophthalmology·J T WhitsonR D Schoenwald
Aug 1, 1987·Journal of Pharmaceutical Sciences·I AhmedT F Patton
Jan 17, 2002·The Annals of Pharmacotherapy·J A Vander ZandenG I Wortman
Jul 11, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Juha-Matti KorteK Matti Saari
Oct 18, 2002·American Journal of Ophthalmology·Frederick W FraunfelderBree Jensvold
Mar 5, 2004·Survey of Ophthalmology·Luc Van Santvliet, Annick Ludwig
Jun 9, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ken-ichi HosoyaKwang-Jin Kim
Feb 22, 2011·Journal of Glaucoma·Raghav GuptaTanuj Dada
May 24, 2011·Handbook of Clinical Neurology·Janet C Rucker
Apr 20, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Artur Maliborski, Radosław Różycki
Dec 23, 2014·Therapeutic Delivery·Peter W J Morrison, Vitaliy V Khutoryanskiy
Jan 1, 2013·World Journal of Pharmacology·Ashaben PatelAshim K Mitra
Mar 20, 2015·JAMA Ophthalmology·Bethany StavertRobert P Finger
Apr 29, 2015·Ophthalmology·Paula Anne Newman-CaseyPaul P Lee
Sep 12, 2015·Journal of Clinical Pharmacology·Gary D Novack, Alan L Robin
May 11, 2016·British Journal of Clinical Pharmacology·Daniel R MoralesBruce Guthrie
Oct 21, 2016·Expert Opinion on Drug Safety·Jukka Mäenpää, Olavi Pelkonen
Dec 21, 2016·Clinical Ophthalmology·Andre FarkouhMartin Czejka

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
pregnancy test

Software Mentioned

Excel
Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.