High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones

Organic & Biomolecular Chemistry
Agnieszka CholewiakPiotr Kwiatkowski

Abstract

The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (<10%) of products were formed after 20 h.

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Citations

Mar 7, 2020·ChemSusChem·Domimika KristofikovaRadovan Sebesta
Oct 24, 2020·Journal of Peptide Science : an Official Publication of the European Peptide Society·Isabella RimoldiSara Pellegrino
Oct 23, 2021·Chemistry : a European Journal·Guguloth ThirupathiDhevalapally B Ramachary

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