High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man

Pharmaceutisch Weekblad. Scientific Edition
T B VreeY A Hekster

Abstract

A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, less than 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.

References

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Citations

Oct 16, 1992·Pharmaceutisch Weekblad. Scientific Edition·T B VreeY A Hekster
Nov 1, 1992·The Annals of Pharmacotherapy·T B VreeP G Anderson

Related Concepts

sulfaphenazole-N2-glucuronide
N4-acetylsulfaphenazole
Acetylation
High Pressure Liquid Chromatography Procedure
Glucuronic Acids
Exo-beta-D-Glucuronidase
Half-Life
Plasma Protein Binding Capacity
Sulfaphenazole

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