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High-pressure liquid chromatographic evaluation of cyclic paracetamol-acetylsalicylate and its active metabolites with results of a comparative pharmacokinetic investigation in the rat

Arzneimittel-Forschung

Jul 1, 1990

Antonio MarzoC Lucarelli

PMID: 1977396

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Abstract

Like benorilate, its correlated open ester, MR 897, a cyclic ester between acetylsalicylic acid and paracetamol, gives rise to acetylsalicylic acid, salicylic acid and paracetamol by enzymatic hydrolysis. An analytical method was developed, which detects parent drugs and active metaboli...read more

Mentioned in this Paper

Zorprin
Drug or Chemical Tissue Distribution
Aspirin
Acamol
Salicylic Acids
Benorilate
Salicylic Acid
Acetanilides
Acetaminophen
Spectrophotometry, Ultraviolet
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High-pressure liquid chromatographic evaluation of cyclic paracetamol-acetylsalicylate and its active metabolites with results of a comparative pharmacokinetic investigation in the rat

Arzneimittel-Forschung

Jul 1, 1990

Antonio MarzoC Lucarelli

PMID: 1977396

DOI:

Abstract

Like benorilate, its correlated open ester, MR 897, a cyclic ester between acetylsalicylic acid and paracetamol, gives rise to acetylsalicylic acid, salicylic acid and paracetamol by enzymatic hydrolysis. An analytical method was developed, which detects parent drugs and active metaboli...read more

Mentioned in this Paper

Zorprin
Drug or Chemical Tissue Distribution
Aspirin
Acamol
Salicylic Acids

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