High Pretreatment Plasma D-dimer Levels Are Associated With Poor Prognosis in Patients With Ovarian Cancer Independently of Venous Thromboembolism and Tumor Extension

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Manabu SakuraiHiroyuki Yoshikawa

Abstract

Elevated plasma D-dimer (DD) is associated with decreased survival among patients with breast, lung, and colon cancers. The present study clarifies the prognostic significance of pretreatment plasma DD levels in patients with epithelial ovarian cancer (EOC). We investigated pretreatment DD levels and other variables for overall survival using univariate and multivariate analyses in 134 consecutive patients with EOC stages II to IV who were initially treated between November 2004 and December 2010. The median follow-up period was 53 (7-106) months. Univariate analysis significantly associated elevated pretreatment DD (≥2.0 μg/mL) levels to poor 5-year overall survival rates irrespective of previously treated venous thromboembolism (72.2% vs 52.6%, P = 0.039). Cancer antigen 125 levels of 200 U/mL or higher (P = 0.011), distant metastases (P = 0.0004), residual tumors (P < 0.0001), and International Federation of Gynecology and Obstetrics stage III/IV (P = 0.0033) were also poor prognostic factors. Multivariate analysis independently associated DD levels of 2.0 μg/mL or higher (P = 0.041), distant metastases (P = 0.013), and residual tumors (P < 0.0001) with poor overall survival. High pretreatment DD levels are associated with p...Continue Reading

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Citations

Mar 27, 2016·Laboratory Medicine·Roger S RileyRichard A McPherson
Nov 5, 2016·International Journal of Cancer. Journal International Du Cancer·Anna DeschStefan W Schneider
Jun 8, 2018·Medicine·Yasuhiko EbinaHideto Yamada
Feb 14, 2019·Cancer Chemotherapy and Pharmacology·Xujiao ChenZhaoyu Liu
Jun 20, 2018·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Sep 12, 2017·The Cochrane Database of Systematic Reviews·Elie A AklHolger Schünemann
Dec 30, 2017·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Jul 25, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Yuki YamadaHiroshi Kobayashi
Mar 10, 2020·The Journal of Obstetrics and Gynaecology Research·Nobutaka TasakaToyomi Satoh
Mar 20, 2020·BioMed Research International·Yi LiuShan-Shan Luo
Aug 28, 2021·Seminars in Thrombosis and Hemostasis·Anna FalangaLaura Russo

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Methods Mentioned

BETA
hysterectomy
biopsies
biopsy

Software Mentioned

JMP

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