High prevalence and diversity of hepatitis B and hepatitis delta virus in Gabon

Journal of Viral Hepatitis
Soraya GrocPierre Becquart

Abstract

Although central Africa is classified as having a high endemicity of hepatitis B virus (HBV) and hepatitis D virus (HDV) infection, there is paucity of prevalence studies. For the first time on a country-wide level in Central Africa, we show in Gabon an overall 7.4% prevalence of Hepatitis B surface antigen (HBsAg) and that more than 25% of the HBsAg-positive population are infected by HDV. Although HBV prevalence did not differ significantly between provinces, there is a north-south split in the distribution of HDV seroprevalence, with the highest rates (>66.0%) correlating with the presence of specific ethnic groups in the northeastern provinces. Genotyping revealed high genetic diversity of the HBV and HDV strains circulating in Gabon, including many restricted to this region of the globe. This work confirmed that high exposure to HBV and HDV infection reported in selected regions of Gabon holds true across the whole country.

References

Mar 1, 1986·American Journal of Epidemiology·C GreenfieldB M Wankya
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·M BasarasR Cisterna
Oct 17, 2001·The Journal of General Virology·V IvaniushinaP Dény
Jan 8, 2004·Journal of Hepatology·Patrizia Farci
Jul 19, 2006·Journal of Medical Virology·Maria MakuwaFrançois Simon
Mar 27, 2007·Virus Research·Alan Kay, Fabien Zoulim
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anna Kramvis, Michael C Kew
Aug 11, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Claudine BekondiVéronique Venard
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Mario Rizzetto
Feb 4, 2010·World Journal of Gastroenterology : WJG·Zaigham AbbasSajjad Raza
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Jan 7, 2011·Journal of Clinical Microbiology·Yacouba FoupouapouognigniRichard Njouom
Aug 31, 2012·Seminars in Liver Disease·Patrizia Farci, Grazia Anna Niro
Dec 7, 2013·PloS One·Iris E AndernachClaude P Muller
Mar 7, 2014·Journal of Clinical Microbiology·Iris E AndernachClaude P Muller
Jul 19, 2014·Intervirology·Anna Kramvis
Sep 1, 2011·Journal of Clinical and Experimental Hepatology·Rajesh KumarJasbir Singh
Apr 8, 2015·World Journal of Hepatology·Catherine Mn CroaghSally J Bell
Jul 3, 2015·Cold Spring Harbor Perspectives in Medicine·Mario Rizzetto
Jan 10, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sandrine François-SouquièreMirdad Kazanji
Jun 9, 2016·The American Journal of Tropical Medicine and Hygiene·Kathleen N LyEyasu H Teshale
Aug 19, 2016·Nature Reviews. Gastroenterology & Hepatology·Florian A LemppStephan Urban
Sep 22, 2016·Infectious Agents and Cancer·Brunel Monic AngoundaJean-Rosaire Ibara
Feb 10, 2017·Health Promotion International·UNKNOWN World Health Organization
Feb 17, 2017·Journal of Clinical Microbiology·Sheila Makiala-MandandaPierre Becquart
Jul 27, 2017·Vaccine· World Health Organization
Sep 16, 2017·The Lancet Global Health·Alexander J StockdaleAnna Maria Geretti
Oct 11, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frédéric Le GalEmmanuel Gordien

❮ Previous
Next ❯

Citations

Feb 16, 2020·Gut·Anders Boyd, Gilles Wandeler
Jan 8, 2020·Gut·Camille BesombesArnaud Fontanet
Jan 24, 2021·Journal of Hepatology·Mario RizzettoFranco Negro
Jun 14, 2019·Journal of Advanced Research·Nathalie MenthaDulce Alfaiate

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.