High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases

Gastroenterology
Bing-Fang ChenDing-Shinn Chen

Abstract

The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study. The sequences of the pre-S region and the BCP (A1762T, G1764A) and PC (G1896A) mutations were determined in 46 HBV chronic carriers (CC) and 106 age-matched carriers with different stages of liver diseases, including 38 chronic hepatitis (CH), 18 cirrhosis (LC), and 50 hepatocellular carcinoma (HCC). A higher prevalence of pre-S deletion and BCP and PC mutations was found in carriers with progressive liver diseases compared with the CC group. By logistic regression analysis, patients with pre-S deletion and BCP mutation were significantly associated with the development of progressive liver diseases than those without. Combination of mutations rather than single mutation was associated with the development of progressive liver diseases, especially in combination with pre-S deletion. Sequencing analysis showed that the deleted regions were more often in the 3' terminus of pre-S1 and the 5' terminus of pre-S2. Further mapping of these pre-S deletion sequences found that all the deletion regions encompassed T- and...Continue Reading

Citations

Jul 4, 2009·Journal of the National Cancer Institute·Shijian LiuGuangwen Cao
Mar 6, 2008·Journal of Gastroenterology and Hepatology·Chun-Jen Liu, Jia-Horng Kao
Jan 22, 2010·Journal of Virology·Hurng-Yi WangDing-Shinn Chen
Feb 9, 2012·Journal of Biomedical Science·Chih-Ming LinBing-Fang Chen
Jul 31, 2008·World Journal of Gastroenterology : WJG·Asmaa-Ibrahim GomaaSimon-D Taylor-Robinson
Dec 10, 2009·World Journal of Gastroenterology : WJG·Guang-Wen Cao
May 31, 2014·World Journal of Gastroenterology : WJG·Li-Shuai Qu, Guo-Xiong Zhou
Mar 5, 2015·Hepatitis Monthly·Jeyanthi SuppiahZainah Saat
Jul 16, 2014·International Journal of Molecular Sciences·Tsung-Lin ChengJui-Hsiang Hung
Aug 23, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kamol SuwannakarnYong Poovorawan
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jia-Horng Kao
Oct 23, 2012·Hepatitis Monthly·Seyed Moayed AlavianSeyed Mohammad Jazayeri
Sep 6, 2014·Frontiers in Microbiology·Catalin LazarNorica Branza-Nichita
Oct 10, 2009·Pediatric Research·Hsiang-Po HuangMei-Hwei Chang
Jul 7, 2007·Archives of Medical Research·Gabriela Gutierrez-ReyesDavid Kershenobich
Mar 27, 2010·Biomedical and Environmental Sciences : BES·Su-Zhen JiangHui Zhuang
Feb 10, 2018·Journal of Gastroenterology and Hepatology·Christopher Sung-Huan YehChau-Ting Yeh
Nov 21, 2017·The Journal of Infectious Diseases·Hung-Chih YangChun-Jen Liu
May 4, 2018·Alimentary Pharmacology & Therapeutics·C-L Lin, J-H Kao

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