High prevalence and risk factors of thromboembolism in stage IV melanoma

Journal of the European Academy of Dermatology and Venereology : JEADV
A SparsaJ-M Bonnetblanc

Abstract

Patients with cancer are at a high risk of thromboembolism (TE), which contributes to morbidity and mortality. Several case reports of thromboembolic events have been reported in patients with melanoma in the literature. The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in stage IV melanoma and determine risk factors, outcomes associated with the development of VTE and the number of haemorrhagic complications in patients under anti-coagulant treatment. In this retrospective study, we included all consecutive patients with stage IV melanoma among 290 patients followed-up in the department of Dermatology each year between January 2005 and 31 December 2007. The diagnosis of VTE was confirmed by venous ultrasound, pulmonary perfusion-ventilation technetium scan and angiography. The primary outcome was to evaluate the number of TE diagnosed in stage IV melanoma patients. The secondary outcomes were to study the influence of TE on survival, its prevalence according to metastatic sites and to evaluate the number of haemorrhagic complications. Twenty-four VTE events were found [25.2% (CI: 16.5-34)]. Eighteen VTE were deep venous thrombosis in lower limbs associated with pulmonary embolism (PE) in 50% ...Continue Reading

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Citations

Oct 20, 2011·Cancer Research·Maya ZiglerMenashe Bar-Eli
Aug 23, 2020·Journal of Clinical Medicine·Gustavo R RossiFernando Souza-Fonseca-Guimaraes
Feb 12, 2017·The Australasian Journal of Dermatology·Sarah Kym Morton, Adam Park Morton
Dec 29, 2020·Frontiers in Oncology·Charlotte Nicole HillGareth I Owen

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