High Prevalence and Widespread Distribution of Zoonotic Enterocytozoon bieneusi Genotypes in Swine in Northeast China: Implications for Public Health

The Journal of Eukaryotic Microbiology
Qiang WanWei Li

Abstract

This study analyzed 563 fecal specimens of asymptomatic pigs from five cities of northeast China for the prevalence and genetic characteristics of Enterocytozoon bieneusi. The parasite was detected in 267 of 563 (47.4%) pigs by nested PCR of the ribosomal internal transcribed spacer (ITS). The differences in prevalence between preweaned (58.0%, 94/162) and growing pigs (39.6%, 114/288) and between weaned (52.2%, 59/113) and growing pigs are significant (p < 0.05). Genotypic typing and phylogenetic analysis facilitated identification of six human-pathogenic genotypes EbpC, O, CS-4, EbpA, Henan-IV, and PigEBITS5 and six potentially zoonotic genotypes EbpB, CC-1, CS-1, CS-3, CHN7, and CS-10. Genotypes CS-4 (32/35) and EbpC (3/35) from Harbin and Henan-IV (5/64) from Qiqihar determined in pigs herein represented the main causative agents of human microsporidiosis in Harbin. The most dominant genotype EbpC found in pigs from Daqing (35/65) and Qiqihar (a close neighbor to Daqing) (47/64) contributed significantly to human infections in Daqing. Genotype EbpC was also a leading E. bieneusi pathogen in humans, drinking water, and wastewater in central China. This study provided robust evidence that pigs could be an outstanding source o...Continue Reading

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Citations

Jul 31, 2016·Research in Veterinary Science·Vagner Ricardo da Silva FiuzaMonica Santín
Feb 26, 2016·The Journal of Eukaryotic Microbiology·Meng QiLongxian Zhang
Mar 9, 2019·The Journal of Eukaryotic Microbiology·Onder DuzluAbdullah Inci
May 2, 2019·Parasite : Journal De La Société Française De Parasitologie·Run LuoGuangneng Peng
Aug 30, 2019·BMC Veterinary Research·Ruenruetai UdonsomSupaluk Popruk
Sep 16, 2019·BMC Infectious Diseases·Rapeepun PrasertbunAongart Mahittikorn
Nov 7, 2019·Frontiers in Microbiology·Dong-Fang LiLong-Xian Zhang

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