High prevalence of antibodies against circumsporozoite antigen of Plasmodium falciparum without development of symptomatic malaria in travelers returning from sub-Saharan Africa

The Journal of Infectious Diseases
T JelinekH D Nothdurft

Abstract

Circumsporozoite (CS) antibodies, indicating that falciparum malaria infection has occurred, have been shown to be reliable indicators of transmission in malaria-endemic areas. In order to estimate the actual rate of malaria infection, the prevalence of CS antibodies in serum was investigated by ELISA in a selected population of travelers returning from sub-Saharan Africa without any clinical sign of malaria. Sera from 39 (48.8%) of 80 individual travelers were positive, while this was only true for 8 (5.6%) of 142 travelers who took package tours. The risk of malaria infection was therefore 8.7 times greater for individual tourists than for package-tour travelers. These data demonstrate the importance of adequate malaria chemoprophylaxis in nonimmune travelers to areas with highly endemic disease.

Citations

Dec 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Yousif A Abu-ZeidYupin Charoenvit
Aug 9, 2002·Tropical Medicine & International Health : TM & IH·M KnappikT Jelinek
Dec 5, 2009·Malaria Journal·An-Emmie NiemanAndré van der Ven
Feb 11, 2005·Infectious Disease Clinics of North America·Lin H Chen, Jay S Keystone
Jun 26, 1999·Journal of Travel Medicine·P Schlagenhauf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.