High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

Human Immunology
C SjöwallS Almer

Abstract

The presence of autoantibodies against C-reactive protein (anti-CRP) has been reported in association with autoimmunity and histopathology in chronic hepatitis C virus (HCV) infection. Resistin could play a role in the pathogenesis of hepatitis, although results on HCV infection are ambiguous. Here we retrospectively analyzed anti-CRP and resistin levels in the sera of 38 untreated and well-characterized HCV patients at the time of their first liver biopsy. HCV activity and general health were assessed by a physician at least yearly until follow-up ended. Anti-CRP and resistin were also measured in patients with autoimmune hepatitis (AIH) and nonalcoholic fatty liver disease (NAFLD). Anti-CRP antibodies were registered in all HCV patients, whereas only a few AIH (11%) and NAFLD (12%) sera were positive. Anti-CRP levels were related to histopathological severity and were highest in patients with cirrhosis at baseline. Resistin levels were similar in HCV, AIH, and NAFLD patients, but high levels of resistin were associated with early mortality in HCV patients. Neither anti-CRP nor resistin predicted a response to interferon-based therapy or cirrhosis development or was associated with liver-related mortality. We conclude that ant...Continue Reading

References

Jul 1, 1988·Clinical Immunology and Immunopathology·R F ReesL A Potempa
Jun 1, 1985·The Journal of Experimental Medicine·F A RobeyA D Steinberg
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Apr 28, 2006·Journal of Gastroenterology and Hepatology·Jean Michel PetitPatrick Hillon
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Nov 23, 2006·Biochemical and Biophysical Research Communications·Christopher SjöwallPentti Tengvall
Jan 24, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christopher Sjöwall, Jonas Wetterö
Mar 10, 2007·Current Medicinal Chemistry·A Kessel, E Toubi
Mar 11, 2008·Lancet·Detlef Schuppan, Nezam H Afdhal
May 1, 2008·Endocrine·Chun Hua ShengGui Zhen Zhang
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Emmanuel TsochatzisAthanasios J Archimandritis
Nov 1, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jonas WetteröChristopher Sjöwall
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Dan Buskila
Mar 4, 2010·Apoptosis : an International Journal on Programmed Cell Death·Kristin KruseMartin Herrmann
Sep 4, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ying TanMing-Hui Zhao
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Laurent Castera, Pierre Bedossa
Feb 5, 2011·Seminars in Immunology·Lars RönnblomMaija-Leena Eloranta

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Citations

Sep 10, 2013·Genetic Testing and Molecular Biomarkers·Yanbin ZhuFengling Zhuo
Sep 19, 2012·Clinical & Developmental Immunology·Takashi Himoto, Tsutomu Masaki
Mar 25, 2014·World Journal of Gastroenterology : WJG·Deng-Ho YangJenn-Haung Lai
Oct 30, 2013·ISRN Inflammation·Terry W Du Clos
Dec 5, 2014·Journal of Virology·Jenny W CheRaymond M Welsh
Jan 29, 2016·World Journal of Gastroenterology : WJG·Ming-Ling Chang
Nov 11, 2020·International Journal of Molecular Sciences·Ming-Ling ChangSien-Sing Yang

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