PMID: 11929554Apr 4, 2002Paper

High prevalence of cfxA beta-lactamase in aminopenicillin-resistant Prevotella strains isolated from periodontal pockets

Oral Microbiology and Immunology
Thierry FosseS Ourang

Abstract

This prospective study was designed to investigate amoxicillin-resistant oral anaerobes, and to identify their beta-lactamase-encoding genes. Three subgingival bacterial samples were collected from 12 patients suffering from periodontitis. One to seven beta-lactamase-producing strains were obtained from each patient, mostly belonging to the Prevotella genus (Bacteroides eggerthii, 2/35 strains; Prevotella sp., 33/35 strains). PCR assays were used to detect cfxA and cepA/cblA, the genes encoding class A/group2e beta-lactamases previously described in the Bacteroides fragilis group. The present investigation confirmed the role of Prevotella species as beta-lactamase producers in periodontal pockets. Additionally, this PCR screening showed (1): the high prevalence of CfxA beta-lactamase production by aminopenicillin-resistant Prevotella (32/33: 97.0% positive strains) vs. cepA/cblA (1/33: 3.0% positive strains), and (2) the presence of cfxA in the periodontal reservoir in the absence of antimicrobial therapy during the previous 6 months.

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Citations

May 10, 2005·Journal of Photochemistry and Photobiology. B, Biology·Peter Meisel, Thomas Kocher
Jun 6, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jean-Louis SixouMartine Bonnaure-Mallet
Jan 18, 2002·Antimicrobial Agents and Chemotherapy·C Jeffrey Smith
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Trude HandalThierry Fosse
Dec 8, 2010·Future Microbiology·Corentine AlauzetAlain Lozniewski
Jul 27, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Rajvir MalikD K Suresh
Mar 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jung-Hyun OhJin-Yong Lee
Feb 26, 2014·Journal of Endodontics·Francisco MontagnerBrenda Paula Figueiredo de Almeida Gomes
Aug 28, 2004·Periodontology 2000·Makoto UmedaIsao Ishikawa
Nov 24, 2012·Journal of Periodontal Research·T E RamsA J van Winkelhoff
Jul 25, 2015·Anaerobe·Zohreh Tamanai-ShacooriAnne Jolivet-Gougeon
Dec 4, 2014·International Journal of Antimicrobial Agents·Clarisse DupinAnne Jolivet-Gougeon
Jun 5, 2002·Journal of Endodontics·Adriano PiattelliMassimiliano Fioroni
Jul 23, 2016·PLoS Neglected Tropical Diseases·Irina V SaltykovaPaul J Brindley
Apr 28, 2016·Journal of Applied Oral Science : Revista FOB·Buhle Binta, Mrudula Patel
Jun 22, 2018·Journal of Dental Research·S JiangY Li
Nov 26, 2015·Antimicrobial Agents and Chemotherapy·Eun-Young JangJin-Yong Lee
Nov 24, 2016·Clinical and Experimental Dental Research·Masaaki TakeshitaFusanori Nishimura

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