High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections among HIV-1 negative men who have sex with men in coastal Kenya.

Sexually Transmitted Infections
Eduard J SandersSusan M Graham

Abstract

To assess the burden of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in high-risk HIV-1 negative men who have sex with men (MSM) in Africa. Before the start of a pre-exposure prophylaxis trial, HIV-1 negative volunteers were screened for sexually transmitted infection (STI) including CT and NG, using a highly sensitive and specific nucleic acid amplification test. Samples positive for CT by Aptima testing, were evaluated for the presence of lymphogranuloma venereum (LGV) serovars using an in-house PCR assay. All men were asked to submit a urine specimen, and all had a rectal swab collected by a clinician. Men were asked if they had dysuria, urethral or rectal discharge, or rectal pain. 43 HIV-1 negative MSM were screened, of whom 13 reported sex with men only; the majority (27/43) reported sex work. One volunteer had dysuria and another, rectal pain. Eleven MSM (26%, 95% CI 14% to 41%) had infections with either or both pathogens. Homosexual men had a higher prevalence of any infection than bisexual men (46% vs 17%, p=0.04), and all cases of rectal infections, including one with CT, two with NG and two with CT/NG co-infection. All patients with CT were negative for LGV. One patient with a rectal NG infection report...Continue Reading

Citations

Aug 21, 2013·AIDS Research and Human Retroviruses·Daniela BezemerEduard J Sanders
Dec 18, 2013·Sexually Transmitted Infections·Lyle R McKinnonJoshua Kimani
Jan 1, 2014·Journal of Clinical Medicine·Patrick PhilibertPhilippe Halfon
Apr 28, 2018·The Journal of Infectious Diseases·Ana CehovinChristoph M Tang
Aug 18, 2018·International Journal of STD & AIDS·Charlotte M HoffmanRemco Ph Peters
Jan 31, 2018·Sexually Transmitted Infections·Trevor A CrowellUNKNOWN TRUST/RV368 Study Group
Aug 31, 2019·Journal of the International AIDS Society·Teodora Ec WiMagnus Unemo
Mar 25, 2014·Expert Review of Anti-infective Therapy·Nynke Hesselina Neeltje de Vrieze, Henry John Christiaan de Vries
Sep 11, 2019·Sexual Health·Robert D KirkcaldyGwenda Hughes
Jul 14, 2020·Wellcome Open Research·Caroline J NgetsaEduard J Sanders
Sep 2, 2020·Antimicrobial Agents and Chemotherapy·Liteboho D MadunaRemco P H Peters
Jan 25, 2020·Sexually Transmitted Infections·Fredrick OtienoSupriya D Mehta
May 8, 2021·Sexually Transmitted Infections·Jean Olivier Twahirwa RwemaStefan Baral

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