Abstract
Recent reports of the rapid evolution of bacterial resistance in India require urgent antibiotic stewardship programs. This study aimed to define the magnitude and pattern of resistance of bacterial pathogens to guide empirical therapy. We prospectively collected consecutive, clinically significant, and nonduplicate bacterial isolates from each patient from two hospitals in Ujjain, India. The antibiotic susceptibility of the bacteria was tested using a disc diffusion method as recommended by the Clinical and Laboratory Standards Institute. A total of 716 pathogens were isolated from 2568 patients (median age, 25 years; range, 0 days to 92 years). Gram-negative infections were predominant (62%). The isolated pathogens included Staphylococcus aureus (n = 221; 31%), Escherichia coli (n = 149; 21%), Pseudomonas aeruginosa (n = 127; 18%), and Klebsiella pneumoniae (n = 107; 15%). Common diagnoses included abscesses (56%), urinary tract infections (14%), blood stream infections (10%), pneumonia (10%), and vaginal infections (10%). In E. coli isolates, 69% (95% confidence interval [CI] 61.6-76.6) were extended-spectrum β-lactamase (ESBL) producers and 41% (95% CI 31.6-50.5) of K. pneumoniae isolates were ESBL producers. These isolates...Continue Reading
References
Jul 1, 1988·Reviews of Infectious Diseases·V JarlierA Philippon
Aug 5, 1998·Social Science & Medicine·V R Kamat, M Nichter
Feb 15, 2005·Lancet·Herman GoossensUNKNOWN ESAC Project Group
Mar 9, 2007·Journal of Clinical Microbiology·Jan M BellRonald N Jones
May 29, 2007·International Journal of Antimicrobial Agents·Douglas J BiedenbachJohn D Turnidge
May 1, 2008·Indian Journal of Medical Microbiology·V Lakshmi
Sep 20, 2008·BMJ : British Medical Journal·Otto CarsGöran Tomson
Jun 13, 2009·The Journal of Antimicrobial Chemotherapy·Ali A El Solh, Ahmad Alhajhusain
Oct 7, 2009·Indian Journal of Pathology & Microbiology·Dwivedi MayankKashi N Prasad
Aug 14, 2010·The Lancet Infectious Diseases·Karthikeyan K KumarasamyNeil Woodford
Oct 23, 2010·BMC Public Health·Krushna Chandra SahooCecilia Stålsby Lundborg
Dec 30, 2010·Antimicrobial Agents and Chemotherapy·Mariana CastanheiraRodrigo E Mendes
Feb 9, 2011·Scandinavian Journal of Infectious Diseases·Ashish PathakCecilia Stålsby Lundborg
Mar 9, 2011·International Journal of Antimicrobial Agents·Shio-Shin Jean, Po-Ren Hsueh
Mar 29, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Gunnar AlvanAndreas Heddini
Apr 12, 2011·Lancet·Jean CarletAndreas Voss
Jun 2, 2011·Journal of Infection in Developing Countries·Syed Ahmed Zaki, Sunil Karande
Jun 10, 2011·Indian Journal of Nephrology·M EshwarappaP Kempegowda
Jun 29, 2011·Tropical Medicine & International Health : TM & IH·Elizabeth A AshleyPaul Turner
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Aug 24, 2011·Indian Journal of Medical Microbiology·S Bhattacharya
Citations
Apr 4, 2014·Journal of Laboratory Physicians·Sridhar Pn RaoKrishna Srinivasan
Jan 30, 2015·Jundishapur Journal of Microbiology·Abolfazl GholipourAzar Baradaran
Mar 22, 2014·Critical Reviews in Microbiology·Saeed AkhtarNaima Fasih
Aug 2, 2015·American Journal of Infection Control·Cecilia LindsjöAshish Pathak
May 13, 2015·Tropical Medicine & International Health : TM & IH·Lauren ChalmersRose McGready
May 4, 2013·BMC Infectious Diseases·Ashish PathakCecilia Stålsby Lundborg
Nov 28, 2013·BMC Research Notes·Anil Chander, Chandrika Devi Shrestha
Dec 31, 2015·BMC Public Health·Cecilia Stålsby LundborgAshok J Tamhankar
Jan 27, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Dilip ChandrasekharVikas Pokkavayalil
Sep 17, 2019·Perioperative Medicine·Anna MachowskaMegha Sharma
Oct 12, 2018·International Journal of Microbiology·Abdulaziz AlqasimAbdullah A Alyousef
Feb 23, 2020·BMC Infectious Diseases·Ashish PathakCecilia Stålsby Lundborg
May 3, 2020·Journal of Cardiothoracic Surgery·Sanaa Saeed Mekdad, Leenah AlSayed
Nov 26, 2020·Journal of Infection and Public Health·Sureka IndrajithSaravanan Muthupandian