High prevalence of extended-spectrum β-lactamase-producing pathogens: results of a surveillance study in two hospitals in Ujjain, India.

Infection and Drug Resistance
Ashish PathakCecilia Stålsby Lundborg

Abstract

Recent reports of the rapid evolution of bacterial resistance in India require urgent antibiotic stewardship programs. This study aimed to define the magnitude and pattern of resistance of bacterial pathogens to guide empirical therapy. We prospectively collected consecutive, clinically significant, and nonduplicate bacterial isolates from each patient from two hospitals in Ujjain, India. The antibiotic susceptibility of the bacteria was tested using a disc diffusion method as recommended by the Clinical and Laboratory Standards Institute. A total of 716 pathogens were isolated from 2568 patients (median age, 25 years; range, 0 days to 92 years). Gram-negative infections were predominant (62%). The isolated pathogens included Staphylococcus aureus (n = 221; 31%), Escherichia coli (n = 149; 21%), Pseudomonas aeruginosa (n = 127; 18%), and Klebsiella pneumoniae (n = 107; 15%). Common diagnoses included abscesses (56%), urinary tract infections (14%), blood stream infections (10%), pneumonia (10%), and vaginal infections (10%). In E. coli isolates, 69% (95% confidence interval [CI] 61.6-76.6) were extended-spectrum β-lactamase (ESBL) producers and 41% (95% CI 31.6-50.5) of K. pneumoniae isolates were ESBL producers. These isolates...Continue Reading

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Citations

Jan 27, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Dilip ChandrasekharVikas Pokkavayalil
May 3, 2020·Journal of Cardiothoracic Surgery·Sanaa Saeed Mekdad, Leenah AlSayed
Nov 26, 2020·Journal of Infection and Public Health·Sureka IndrajithSaravanan Muthupandian

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Methods Mentioned

BETA
bronchoalveolar lavage

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EpiData Entry
Stata

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